AOP-Wiki

API

All Key Events

Showing 626 to 650 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1066	Promotion, Sine oculis homeobox 1 positive progenitor cells in endometrium Short Name	1	Cellular	Nov 29, 2016	Sep 12, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1067	Proliferation/Clonal Expansion, aberrant basal-type cells Short Name	1	Cellular	Nov 29, 2016	Aug 21, 2025	None
1068	Endometrial squamous metaplasia, Increase Short Name	2	Cellular	Nov 29, 2016	Sep 18, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1069	Increased, Hyperplasia (glandular epithelial cells of endometrium) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
1070	Increased, adenosquamous carcinomas of endometrium Short Name	2	Tissue	Nov 29, 2016	Sep 18, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1071	Decreased, GnRH pulsatility/release in hypothalamus Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1072	Decreased, LH Surge from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1073	anovulation, Short Name anovulation,	0		Nov 29, 2016	Nov 29, 2016	None
1074	interruption, Ovulation Short Name interruption, Ovulation	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1075	prolonged, estrus cycle Short Name prolonged, estrus cycle	2	Individual	Nov 29, 2016	Oct 3, 2025	3 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
1076	Increased, circulating estrogen levels Short Name Increased, circulating estrogen levels	1	Organ	Nov 29, 2016	Dec 3, 2016	4 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
1077	Increased, prolactin exposure Short Name Increased, prolactin exposure	1	Tissue	Nov 29, 2016	Dec 3, 2016	168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1078	Hyperplasia, Mammary gland Short Name Hyperplasia, Mammary gland	1	Tissue	Nov 29, 2016	Sep 16, 2017	168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1079	Increased, Adenomas/carcinomas (mammary) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1080	Increased, latency period Short Name Increased, latency period	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1081	Increased, lactotroph hyperplasia and hypertrophy Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1082	Increased, adenomas (pituitary) Short Name Increased, adenomas (pituitary)	1	Tissue	Nov 29, 2016	Sep 16, 2017	169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1083	Decreased, Dopaminergic activity Short Name Decreased, Dopaminergic activity	1	Cellular	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1084	Increased, prolactin secretion Short Name Increased, prolactin secretion	1	Tissue	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1085	Increased, hyperplasia (mammary gland) Short Name Increased, hyperplasia (mammary gland)	1	Tissue	Nov 29, 2016	Sep 16, 2017	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1086	persistent, cytotoxicity (pleura or peritoneum) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1087	Increased, inflammation Short Name Increased, inflammation	1	Cellular	Nov 29, 2016	Dec 3, 2016	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1089	Increased, Cell Proliferation (mesothelium) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1090	Increased, mesotheliomas Short Name Increased, mesotheliomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. 409: Frustrated phagocytosis leads to malignant mesothelioma
1091	Physical and/or chemical interaction with cellular components, Short Name	0		Nov 29, 2016	Nov 29, 2016	None