AOP-Wiki

API

All Key Events

Showing 1 to 25 of 1947 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2455	Endometriosis Short Name endometriosis	0	Tissue	Sep 11, 2026	Sep 16, 2026	577: AhR activation leading to endometriosis
2454	Increase, small intestine steatosis Short Name small intestine steatosis	0	Organ	Sep 9, 2026	Sep 9, 2026	653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis
2453	reduced efflux of lipid Short Name reduced lipid efflux	0	Cellular	Sep 9, 2026	Sep 9, 2026	653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis
2452	Inhibition to Microsomal Triglyceride Transfer Protein Short Name inhbition to MTP	0	Molecular	Sep 9, 2026	Sep 9, 2026	653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis
2451	Increase, TDP-43 aggregation Short Name TDP-43 aggregation	0	Cellular	Sep 6, 2026	Sep 6, 2026	636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
2450	Cognitive Decline (Adult) Short Name Cognitive Decline (Adult)	0	Individual	Aug 31, 2026	Aug 31, 2026	652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
2449	Brain amyloid-beta (Aβ) accumulation, increased Short Name Abeta accumulation	0	Cellular	Aug 31, 2026	Aug 31, 2026	652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
2448	Brain insulin-degrading enzyme (IDE), inhibition Short Name IDE inhibition	0	Molecular	Aug 31, 2026	Aug 31, 2026	652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
2447	Increase, Keap1 cysteine modification Short Name Keap1 cysteine modification	0	Molecular	Aug 12, 2026	Aug 12, 2026	None
2446	Increase, lipid accumulation Short Name lipid accumulation	0	Tissue	Jul 24, 2026	Jul 24, 2026	2 AOPs 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders 653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis
2445	Increase, Blood pressure Short Name Blood pressure	0	Organ	Jul 24, 2026	Jul 24, 2026	645: Binding and activation of AhR lead to cardiovascular aging
2444	Increase, Progesterone resistance Short Name Progesterone resistance	0	Cellular	Jul 17, 2026	Jul 17, 2026	577: AhR activation leading to endometriosis
2443	Increase, Hepatocyte injury Short Name Hepatocyte injury	0	Tissue	Jul 9, 2026	Jul 9, 2026	None
2442	Increase, Abnormal lipid accumulation Short Name Abnormal lipid accumulation	0	Organ	Jul 9, 2026	Jul 9, 2026	None
2441	Increased , Fatty acid synthesis and transport Short Name	0	Tissue	Jul 9, 2026	Jul 9, 2026	646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
2440	Increase, Hepatic inflammation Short Name Hepatic inflammation	0	Tissue	Jul 9, 2026	Jul 9, 2026	None
2439	Increase, Telomere attrition Short Name Increase, Telomere attrition	0	Molecular	Jul 9, 2026	Jul 9, 2026	645: Binding and activation of AhR lead to cardiovascular aging
2438	Increase, Cardiovascular aging Short Name Cardiovascular aging	0	Individual	Jul 9, 2026	Jul 9, 2026	645: Binding and activation of AhR lead to cardiovascular aging
2437	Increase, Blood pressure elevation Short Name Blood pressure elevation	0	Tissue	Jul 9, 2026	Jul 9, 2026	None
2436	Increase, Systemic inflammation Short Name Systemic inflammation	0	Cellular	Jul 9, 2026	Jul 9, 2026	None
2435	Increase, Myocardial and vascular structural remodeling Short Name	0	Tissue	Jul 9, 2026	Jul 9, 2026	645: Binding and activation of AhR lead to cardiovascular aging
2434	Disruption, Mitochondrial dysfunction Short Name Mitochondrial dysfunction	0	Cellular	Jul 9, 2026	Jul 9, 2026	None
2433	Decrease, Telomere attrition Short Name Telomere attrition	0	Molecular	Jul 9, 2026	Jul 9, 2026	None
2432	Increase, Cell cycle arrest Short Name Cell cycle arrest	0	Cellular	Jul 9, 2026	Jul 9, 2026	645: Binding and activation of AhR lead to cardiovascular aging
2431	Impact on sirtuins-related aging signaling pathway gene expression Short Name	0	Molecular	Jul 9, 2026	Jul 9, 2026	645: Binding and activation of AhR lead to cardiovascular aging