| 2446 |
Increase, lipid accumulation
Short Name
lipid accumulation
|
0 |
Tissue |
Jul 24, 2026 |
Jul 24, 2026 |
646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
|
| 2445 |
Increase, Blood pressure
Short Name
Blood pressure
|
0 |
Organ |
Jul 24, 2026 |
Jul 24, 2026 |
645: Binding and activation of AhR lead to cardiovascular aging
|
| 2444 |
Increase, Progesterone resistance
Short Name
Progesterone resistance
|
0 |
Cellular |
Jul 17, 2026 |
Jul 17, 2026 |
577: AhR activation leading to endometriosis
|
| 2443 |
Increase, Hepatocyte injury
Short Name
Hepatocyte injury
|
0 |
Tissue |
Jul 9, 2026 |
Jul 9, 2026 |
None
|
| 2442 |
Increase, Abnormal lipid accumulation
Short Name
Abnormal lipid accumulation
|
0 |
Organ |
Jul 9, 2026 |
Jul 9, 2026 |
None
|
| 2441 |
Increased , Fatty acid synthesis and transport
Short Name
Increased fatty acid synthesis and transport
|
0 |
Tissue |
Jul 9, 2026 |
Jul 9, 2026 |
646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
|
| 2440 |
Increase, Hepatic inflammation
Short Name
Hepatic inflammation
|
0 |
Tissue |
Jul 9, 2026 |
Jul 9, 2026 |
None
|
| 2439 |
Increase, Telomere attrition
Short Name
Increase, Telomere attrition
|
0 |
Molecular |
Jul 9, 2026 |
Jul 9, 2026 |
645: Binding and activation of AhR lead to cardiovascular aging
|
| 2438 |
Increase, Cardiovascular aging
Short Name
Cardiovascular aging
|
0 |
Individual |
Jul 9, 2026 |
Jul 9, 2026 |
645: Binding and activation of AhR lead to cardiovascular aging
|
| 2437 |
Increase, Blood pressure elevation
Short Name
Blood pressure elevation
|
0 |
Tissue |
Jul 9, 2026 |
Jul 9, 2026 |
None
|
| 2436 |
Increase, Systemic inflammation
Short Name
Systemic inflammation
|
0 |
Cellular |
Jul 9, 2026 |
Jul 9, 2026 |
None
|
| 2435 |
Increase, Myocardial and vascular structural remodeling
Short Name
Myocardial and vascular structural remodeling
|
0 |
Tissue |
Jul 9, 2026 |
Jul 9, 2026 |
645: Binding and activation of AhR lead to cardiovascular aging
|
| 2434 |
Disruption, Mitochondrial dysfunction
Short Name
Mitochondrial dysfunction
|
0 |
Cellular |
Jul 9, 2026 |
Jul 9, 2026 |
None
|
| 2433 |
Decrease, Telomere attrition
Short Name
Telomere attrition
|
0 |
Molecular |
Jul 9, 2026 |
Jul 9, 2026 |
None
|
| 2432 |
Increase, Cell cycle arrest
Short Name
Cell cycle arrest
|
0 |
Cellular |
Jul 9, 2026 |
Jul 9, 2026 |
645: Binding and activation of AhR lead to cardiovascular aging
|
| 2431 |
Impact on sirtuins-related aging signaling pathway gene expression
Short Name
Impact on sirtuins-related aging signaling pathway gene expression
|
0 |
Molecular |
Jul 9, 2026 |
Jul 9, 2026 |
645: Binding and activation of AhR lead to cardiovascular aging
|
| 2430 |
Aryl hydrocarbon receptor（AhR）activation
Short Name
AhR activation
|
0 |
Molecular |
Jul 9, 2026 |
Jul 9, 2026 |
2 AOPs
|
| 2429 |
Instability/dysfunction of INSIG1
Short Name
Instability of INSIG1
|
0 |
Molecular |
Jun 9, 2026 |
Jun 9, 2026 |
None
|
| 2428 |
Gut derived PAMPs, increased
Short Name
PAMPs, increased
|
0 |
Cellular |
Apr 23, 2026 |
Apr 23, 2026 |
642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
|
| 2427 |
Bile acid composition in bile and intestine, altered
Short Name
Bile acid composition, altered
|
0 |
Cellular |
Apr 23, 2026 |
Apr 23, 2026 |
642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
|
| 2426 |
Hepatic BSEP (ABCB11), decreased
Short Name
BSEP (ABCB11), decreased
|
0 |
Cellular |
Apr 23, 2026 |
Apr 23, 2026 |
642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
|
| 2425 |
Intrahepatic bile acid burden, increased
Short Name
Intrahepatic bile acids, increased
|
0 |
Cellular |
Apr 23, 2026 |
Apr 23, 2026 |
642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
|
| 2424 |
Hepatic CYP7A1, increased
Short Name
Hepatic CYP7A1, increased
|
0 |
Cellular |
Apr 22, 2026 |
Apr 22, 2026 |
642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
|
| 2423 |
Hepatic SHP, decreased
Short Name
Hepatic SHP, decreased
|
0 |
Cellular |
Apr 22, 2026 |
Apr 22, 2026 |
232: NFE2/Nrf2 repression to steatosis
|
| 2422 |
Ileal FGF15/FGF19 secretion, decreased
Short Name
Decreased FGF15/FGF19
|
0 |
Cellular |
Apr 22, 2026 |
Apr 22, 2026 |
642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
|