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ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1718	Suppression of IL-4 production Short Name Suppression of IL-4 production	1	Cellular	Jan 5, 2020	Mar 17, 2025	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1719	Impairment of T-cell dependent antibody response Short Name Impairment, TDAR	1	Individual	Jan 5, 2020	Feb 24, 2021	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1869	Diminished protective oxidative stress response Short Name Diminished Protective Response to ROS	3	Cellular	Apr 20, 2021	Oct 30, 2023	5 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 488: Increased reactive oxygen species production leading to decreased cognitive function
2269	Increased, Sterol Regulatory Element Binding Protein 2 (SREBP2) protein expression Short Name Increased, SREBP2 protein expression	1	Cellular	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2318	Decreased 3-beta-HSD activity Short Name Decreased 3βHSD activity	0	Tissue	Apr 8, 2025	Apr 8, 2025	None