API

Stressor: 11

Title

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Bis(2-ethylhexyl) phthalate

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
bis(2-ethylhexyl) phthalate DTXSID5020607 Di(2-ethylhexyl) phthalate 117-81-7 BJQHLKABXJIVAM-UHFFFAOYNA-N BJQHLKABXJIVAM-UHFFFAOYSA-N

AOP Evidence

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PPARalpha-dependent liver cancer

There is no evidence text for this AOP



Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring

There is no evidence text for this AOP




Event Evidence

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Activation, PPARα & PPARγ

There is no evidence text for this event.



Decreased, 11-ketotestosterone

A review of androgen signaling in fish cites several studies showing DEHP decreased 11KT (Golshan et al., 2019)



Impaired, Spermatogenesis

A review of androgen signaling in male fish cites several studies showing DEHP decreases sperm quality (Golshan et al., 2019)



decrease, male anogenital distance

DEHP has been shown to cause decreased male AGD in rats following intrauterine exposure to 300-1500 mg/kg bw/day (Christiansen et al, 2010; Gray et al, 2000; Howdeshell et al, 2007; Jarfelt et al, 2005; Kita et al, 2016; Li et al, 2013; Lin et al, 2009; Moore et al, 2001; Nardelli et al, 2017; Saillenfait et al, 2009; Wolf et al, 1999).




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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