Stressor: 147
Title
Stressor Overview
AOPs Including This Stressor
| AOP Name | Evidence |
|---|---|
| Aryl hydrocarbon receptor activation leading to uroporphyria | High |
Events Including This Stressor
| Event Name |
|---|
| Activation, AhR |
Chemical Table
| User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
|---|---|---|---|---|---|
| Dibenzo-p-dioxin | DTXSID8020410 | Dibenzo-p-dioxin | 262-12-4 | NFBOHOGPQUYFRF-UHFFFAOYSA-N | NFBOHOGPQUYFRF-UHFFFAOYSA-N |
AOP Evidence
Aryl hydrocarbon receptor activation leading to uroporphyria
2,3,7,8-tetrachlordibenzo-p-dioxin causes porphyrin accumulation in mice (Smith et al. 2001; Davies et al. 2008) and chickens (Lorenzen and Kennedy 1995).
Smith, A. G., Clothier, B., Carthew, P., Childs, N. L., Sinclair, P. R., Nebert, D. W., and Dalton, T. P. (2001). Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol.Appl.Pharmacol. 173, 89-98.
Davies, R., Clothier, B., Robinson, S. W., Edwards, R. E., Greaves, P., Luo, J., Gant, T. W., Chernova, T., and Smith, A. G. (2008) Essential role of the AH receptor in the dysfunction of heme metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem. Res. Toxicol. 21 (2), 330-340.
Lorenzen, A., and Kennedy, S. W. (1995). Sensitivities of Chicken and Pheasant Embryos and Cultured Embryonic Hepatocytes to Cytochrome P4501A Induction and Porphyrin Accumulation by TCDD, TCDF and PCBs. Organohalogen Compounds 25, 65-68.
Event Evidence
Activation, AhR
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., and Zhao, B. (2011). Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol.Sci. 124, 1-22.