Stressor: 150
Title
Stressor Overview
AOPs Including This Stressor
| AOP Name | Evidence |
|---|---|
| Aryl hydrocarbon receptor activation leading to uroporphyria | High |
Events Including This Stressor
| Event Name |
|---|
| Activation, AhR |
Chemical Table
| User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
|---|---|---|---|---|---|
| Hexachlorobenzene | DTXSID2020682 | Hexachlorobenzene | 118-74-1 | CKAPSXZOOQJIBF-UHFFFAOYSA-N | CKAPSXZOOQJIBF-UHFFFAOYSA-N |
AOP Evidence
Aryl hydrocarbon receptor activation leading to uroporphyria
Hexachlorobenzene exposure induces porphyria in mice (Hahn 1988), rats (Mylchreest and Charbonneau 1997) and humans (Cripps et al. 1984). A review by Smith and Elder (2010) includes numerouse examples of hexachlorobenzene induced porphyria.
Hahn, M. E., Gasiewicz, T. A., Linko, P., and Goldstein, J. A. (1988) The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice. Biochem. J. 254 (1), 245-254.
Mylchreest, E., and Charbonneau, M. (1997) Studies on the mechanism of uroporphyrinogen decarboxylase inhibition in hexachlorobenzene-induced porphyria in the female rat. Toxicol. Appl. Pharmacol. 145 (1), 23-33.
Cripps, D. J., Peters, H. A., Gocmen, A., and Dogramici, I. (1984) Porphyria turcica due to hexachlorobenzene: a 20 to 30 year follow-up study on 204 patients. Br. J Dermatol. 111 (4), 413-422.
Smith, A.G. and Elder, G.H. (2010) Complex Gene-Chemical Interactions: Hepatic Uroporphyria As a Paradaigm. Chem. Res. Toxicol., 23, 712-723.
Event Evidence
Activation, AhR
Cripps, D. J., Peters, H. A., Gocmen, A., and Dogramici, I. (1984) Porphyria turcica due to hexachlorobenzene: a 20 to 30 year follow-up study on 204 patients. Br. J Dermatol. 111 (4), 413-422.