API

Stressor: 150

Title

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Hexachlorobenzene

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Event Name
Activation, AhR

Chemical Table

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AOP Evidence

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Aryl hydrocarbon receptor activation leading to uroporphyria

Hexachlorobenzene exposure induces porphyria in mice (Hahn 1988), rats (Mylchreest and Charbonneau 1997) and humans (Cripps et al. 1984).  A review by Smith and Elder (2010) includes numerouse examples of  hexachlorobenzene induced porphyria.

Hahn, M. E., Gasiewicz, T. A., Linko, P., and Goldstein, J. A. (1988) The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice. Biochem. J. 254 (1), 245-254.

Mylchreest, E., and Charbonneau, M. (1997) Studies on the mechanism of uroporphyrinogen decarboxylase inhibition in hexachlorobenzene-induced porphyria in the female rat. Toxicol. Appl. Pharmacol. 145 (1), 23-33.

Cripps, D. J., Peters, H. A., Gocmen, A., and Dogramici, I. (1984) Porphyria turcica due to hexachlorobenzene: a 20 to 30 year follow-up study on 204 patients. Br. J Dermatol. 111 (4), 413-422.

Smith, A.G. and Elder, G.H. (2010) Complex Gene-Chemical Interactions: Hepatic Uroporphyria As a Paradaigm. Chem. Res. Toxicol., 23, 712-723.




Event Evidence

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Activation, AhR

Cripps, D. J., Peters, H. A., Gocmen, A., and Dogramici, I. (1984) Porphyria turcica due to hexachlorobenzene: a 20 to 30 year follow-up study on 204 patients. Br. J Dermatol. 111 (4), 413-422.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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