Stressor: 160
Title
Stressor Overview
AOPs Including This Stressor
| AOP Name | Evidence |
|---|---|
| Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity | Low |
Events Including This Stressor
| Event Name |
|---|
| Binding, Transthyretin in serum |
Chemical Table
AOP Evidence
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
Pentachlorophenol is measured in mammals as parent chemical, hexachlorobenzene, and can bind to TTR, like other halogenated phenols (Marchesini et al 2008; van den Berg 1990). Halogenated phenols, such as PCP, have been implicated as thyroid toxicants (Miller et al 2009); however, it appears only 2,4,6-tribromophenol and pentabromophenol can competitively bind TTR (Weiss et al 2015).
Marchesini, G. R., Meimaridou, A., Haasnoot, W., Meulenberg, E., Albertus, F., Mizuguchi, M., … Murk, A. J. (2008). Biosensor discovery of thyroxine transport disrupting chemicals. Toxicology and Applied Pharmacology, 232(1), 150–160. http://doi.org/10.1016/j.taap.2008.06.014
Miller, M. D., Crofton, K. M., Rice, D. C., & Zoeller, R. T. (2009). Thyroid-disrupting chemicals: Interpreting upstream biomarkers of adverse outcomes. Environmental Health Perspectives, 117(7), 1033–1041. http://doi.org/10.1289/ehp.0800247
van den Berg KJ. 1990. Interaction of chlorinated phenols with thyroxine binding sites of human transthyretin, albumin and thyroid binding globulin. Chem Biol Interact 76(1):63–75.
Weiss, J. M., Andersson, P. L., Zhang, J., Simon, E., Leonards, P. E. G., Hamers, T., & Lamoree, M. H. (2015). Tracing thyroid hormone-disrupting compounds: database compilation and structure-activity evaluation for an effect-directed analysis of sediment. Analytical and Bioanalytical Chemistry, 5625–5634. http://doi.org/10.1007/s00216-015-8736-9
Event Evidence
Binding, Transthyretin in serum
There is no evidence text for this event.