API

Stressor: 176

Title

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Diethylstilbestrol

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Diethylstilbestrol DTXSID3020465 Diethylstilbestrol 56-53-1 RGLYKWWBQGJZGM-ISLYRVAYSA-N RGLYKWWBQGJZGM-ISLYRVAYSA-N

AOP Evidence

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Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.

There is no evidence text for this AOP




Event Evidence

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Increase of anti-DNA antibody from autoreactive B cell

BPA as well as E2 and diethylstilbestrol (DES) enhanced anti-Br-RBC autoantibody production by B1 cells in vivo.  IgM production by B1 cells in the presence of ED was more prominent on aged BWF1 mice developing lupus nephritis. (Yurino H. 2004).

To examine a direct effect of endocrine disruptors on IgM antibody production by B1 or B2 cells, B1 cells were prepared from peritoneal cells and B2 cells from spleen, B1 or B2 cells were cultured in the presence of endocrine disruptors (E2: 100 nM, DES: 100 nM, BPA: 1 μM) for 4 days (Yurino H. 2004). 

In both (NZB×NZW) F1 and MRL/lpr mice, estrogen treatment exacerbates the lupus disease, with augmented levels of autoantibodies against dsDNA and phospholipids as well as formation of circulating immune complexes (Grimaldi CM. 2002, Peeva E. 2000).




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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