API

Stressor: 218

Title

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metofluthrin

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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The Chemical Table lists chemicals associated with a stressor. This table contains information about the User’s term for a chemical, the DTXID, Preferred name, CAS number, JChem InChIKey, and Indigo InChIKey.

Instructions

To add a chemical associated with a particular stressor, next to the Chemical Table click ‘Add chemical.’ This will redirect you to a page entitled “New Stressor Chemical.’ The dialog box can be used to search for chemical by name, CAS number, JChem InChIKey, and Indigo InChIKey. Searching by these fields will bring forward a drop down list of existing stressor chemicals formatted as “CAS- preferred name” “JChem InChIKey – preferred name” or “Indigo InChIKey- preferred name” depending on which field you perform the search. Select an entity from the drop down list and click ‘Add chemical.’ This will return you to the Stressor Page, where the new record should be in the ‘Chemical Table’ on the page.


AOP Evidence

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Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat

Metofluthrin produced increased liver tumors in male and female Wistar rats at dose levels of 900 and 1800 ppm in the diet for 2 years (Deguchi et al., 2009).  As shown in Table 5 of the AOP for CAR-mediated rodent liver tumors, dose-concordant data supporting all of the Key Events and/or Associative Events in the AOP for CAR have been demonstrated with metofluthrin (Deguchi et al., 2009; Yamada et al., 2009).  Therefore, there is Strong evidence for metofluthrin as an AOP stressor for the CAR-mediated formation of rat liver tumors. 




Event Evidence

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Activation, Constitutive androstane receptor

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Instructions

To edit the “ Stressor Description” section, on a KER page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Stressor Description” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Stressor Description”  section on the page.



Characterization of Exposure

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Instructions

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.



References

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List the bibliographic references to original papers, books or other documents used to support the Stressor.

Instructions

To edit the “References” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “References” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “References” section on the page.