AOPs Including This Stressor
|Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits||High|
Events Including This Stressor
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a meperidine analog intended for illecit use as a ricreative drug resulted in life-long parkinsonism in a number of abusers. MPTP is able to cross the blood-brain-barrier and is actually a pro-toxin which is converted by monoamine oxidase B in astrocytes to the neurotoxic active species 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium ion (MPP+). MPP+ has high affinityfor the DA transporter (DAT), thus preferentially enters dopaminergic neurons where is accumulating in mitochondria to directely inhibit CI and indirectly CII in the respiratory transport chain. (Aguilar et al.2015; pasquali et al.2014).