API

Stressor: 222

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MPP+

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AOP Evidence

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Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a meperidine analog intended for illecit use as a ricreative drug resulted in life-long parkinsonism in a number of abusers. MPTP is able to cross the blood-brain-barrier and is actually a pro-toxin which is converted by monoamine oxidase B in astrocytes to the neurotoxic active species 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium ion (MPP+). MPP+ has high affinityfor the DA transporter (DAT), thus preferentially enters dopaminergic neurons where is accumulating in mitochondria to directely inhibit CI and indirectly CII in the respiratory transport chain. (Aguilar et al.2015; pasquali et al.2014).




Event Evidence

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This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.



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