AOPs Including This Stressor
|Aryl hydrocarbon receptor activation leading to uroporphyria||Moderate|
Events Including This Stressor
High and repeated doses of non-chlorinated AhR polycyclic ligands administered to AHRb mice with iron overload induce a marked hepatic uroporphyria (Francis et al., 1987).
Francis, J. E., & Smith, A. G. (1987). Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. Biochemical and biophysical research communications, 146(1), 13-20.
PAHs are pontent AHR agonists, but due to their rapid metabolism, they cause a transient alteration in AHR-mediated gene expression; this property results in a very different toxicity profile relative to persistent AHR-agonists such as dioxin-like compounds (Denison et al. 2011).
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., and Zhao, B. (2011). Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol.Sci. 124, 1-22.