Stressor: 250
Title
Polycyclic aromatic hydrocarbons (PAHs)
Stressor Overview
AOPs Including This Stressor
AOP Name | Evidence |
---|---|
Aryl hydrocarbon receptor activation leading to uroporphyria | Moderate |
Bulky DNA adducts leading to mutations |
Events Including This Stressor
Event Name |
---|
Activation, AhR |
Bulky DNA adducts, increase |
Chemical Table
AOP Evidence
Aryl hydrocarbon receptor activation leading to uroporphyria
High and repeated doses of non-chlorinated AhR polycyclic ligands administered to AHRb mice with iron overload induce a marked hepatic uroporphyria (Francis et al., 1987).
Francis, J. E., & Smith, A. G. (1987). Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. Biochemical and biophysical research communications, 146(1), 13-20.
Bulky DNA adducts leading to mutations
There is no evidence text for this AOP
Event Evidence
Activation, AhR
PAHs are pontent AHR agonists, but due to their rapid metabolism, they cause a transient alteration in AHR-mediated gene expression; this property results in a very different toxicity profile relative to persistent AHR-agonists such as dioxin-like compounds (Denison et al. 2011).
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., and Zhao, B. (2011). Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol.Sci. 124, 1-22.
Bulky DNA adducts, increase
There is no evidence text for this event.