API

Stressor: 250

Title

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Polycyclic aromatic hydrocarbons (PAHs)

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Event Name
Activation, AhR

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AOP Evidence

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AhR activation leading to early life stage mortality

There is no evidence text for this AOP




Event Evidence

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Activation, AhR

PAHs are pontent AHR agonists, but due to their rapid metabolism, they cause a transient alteration in AHR-mediated gene expression; this property results in a very different toxicity profile relative to persistent AHR-agonists such as dioxin-like compounds (Denison et al. 2011).

 

Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., and Zhao, B. (2011). Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol.Sci. 124, 1-22.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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