API

Stressor: 250

Title

?

Polycyclic aromatic hydrocarbons (PAHs)

Stressor Overview

?


AOPs Including This Stressor

?


Events Including This Stressor

?

Event Name
Activation, AhR

Chemical Table

?

AOP Evidence

?


Aryl hydrocarbon receptor activation leading to uroporphyria

High and repeated doses of non-chlorinated AhR polycyclic ligands administered to AHRb mice with iron overload induce a marked hepatic uroporphyria (Francis et al., 1987).

 

Francis, J. E., & Smith, A. G. (1987). Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. Biochemical and biophysical research communications, 146(1), 13-20.




Event Evidence

?


Activation, AhR

PAHs are pontent AHR agonists, but due to their rapid metabolism, they cause a transient alteration in AHR-mediated gene expression; this property results in a very different toxicity profile relative to persistent AHR-agonists such as dioxin-like compounds (Denison et al. 2011).

 

Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., and Zhao, B. (2011). Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol.Sci. 124, 1-22.




Stressor Info

?



Chemical/Category Description

?



Characterization of Exposure

?



References

?