AOPs Including This Stressor
Events Including This Stressor
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
In this AOP study, Silica nanoparticles was used as stressor. The wide applications of synthetically manufactured amorphous silica nanoparticles (aSiNP) ranges from daily life uses (i.e. food packaging food additives, paints, varnishes, glue, desiccants, plastics, toothpaste, cosmetics, pharmaceuticals, etc.) to diagnostic and biomedical fields (i.e. bioimaging, drug and gene delivery, cancer therapy, etc.). Specifically, aSiNPs are one of the most used nanomaterials in food products and are commercially available food additives (such as, E551, Aerosil 200F or Aerosil 380F, etc.) used as an anticaking agent, as carrier for fragrances/ flavors in foods etc. Hence, the large scale production and use of aSiNP has increased the possible human health concerns related to both consumer, as well as, occupational exposures.