AOPs Including This Stressor
|Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity||Not Specified|
Events Including This Stressor
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
Both dioxins and furans have been reported to bind to TTR (Lans et al 1993) and, similar to PCBs, have been reported as thyroid toxicants (Boas et al 2012; Miller et al 2009)
Boas, M., Feldt-Rasmussen, U., & Main, K. M. (2012). Thyroid effects of endocrine disrupting chemicals. Molecular and Cellular Endocrinology, 355(2), 240–248. http://doi.org/10.1016/j.mce.2011.09.005
Lans, M. C., Klasson-Wehler, E., Willemsen, M., Meussen, E., Safe, S., & Brouwer, A. (1993). STRUCTURE-DEPENDENT, COMPETITIVE INTERACTION OF HYDROXY-POLYCHLOROBIPHENYLS, -DIBENZO-p-DIOXINS AND -DIBENZOFURANS WITH HUMAN TRANSTHYRETIN. Chemico-Biological Interactions, 88, 7–21.
Miller, M. D., Crofton, K. M., Rice, D. C., & Zoeller, R. T. (2009). Thyroid-disrupting chemicals: Interpreting upstream biomarkers of adverse outcomes. Environmental Health Perspectives, 117(7), 1033–1041. http://doi.org/10.1289/ehp.0800247