Stressor: 261

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Tetrabromobisphenol A

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity	Not Specified
SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

Preferred name	DTXID	Casrn	jchem_inchi_key	indigo_inchi_key	User term
3,3',5,5'-Tetrabromobisphenol A	DTXSID1026081	79-94-7	VEORPZCZECFIRK-UHFFFAOYSA-N	VEORPZCZECFIRK-UHFFFAOYSA-N	Tetrabromobisphenol A

References

List of the literature that was cited for this prototypical stressor. More help

Fang, M., Webster, T. F., Ferguson, P. L. and Stapleton, H. M. (2015). Characterizing the peroxisome proliferator-activated receptor (PPARg) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. Environ. Health Perspect. 123, 166–172.

Riu, A., Grimaldi, M., le Maire, A., Bey, G., Phillips, K., Boulahtouf, A., Perdu, E., Zalko, D., Bourguet, W. and Balaguer, P. (2011). Peroxisome Proliferator-Activated Receptor [ gamma ] Is a Target for Halogenated Analogs of Bisphenol A. Perspect. Environ. Heal. Collect. Proquest Hosp. 119, 1227–1232.

Riu, A., Mccollum, C. W., Pinto, C. L., Grimaldi, M., Hillenweck, A., Perdu, E., Zalko, D., Bernard, L., Laudet, V., Balaguer, P., et al. (2014). Halogenated bisphenol-a analogs act as obesogens in zebrafish larvae (Danio rerio). Toxicol. Sci. 139, 48–58.

Suzuki, G., Tue, N. M., Malarvannan, G., Sudaryanto, A., Takahashi, S., Tanabe, S., Sakai, S. I., Brouwer, A., Uramaru, N., Kitamura, S., et al. (2013). Similarities in the endocrine-disrupting potencies of indoor dust and flame retardants by using human osteosarcoma (U2OS) cell-based reporter gene assays. Environ. Sci. Technol. 47, 2898–2908.

ToxCastTM Data. “ToxCastTM Data.” US Environmental Protection Agency. http://www.epa.gov/ncct/toxcast/data.html.

Watt, J. and Schlezinger, J. J. (2015). Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology 331, 66–77.