Stressor: 261
Title
Stressor Overview
AOPs Including This Stressor
| AOP Name | Evidence |
|---|---|
| Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity | Not Specified |
Events Including This Stressor
This table is automatically generated and lists KE’s including this stressor.Chemical Table
The Chemical Table lists chemicals associated with a stressor. This table contains information about the User’s term for a chemical, the DTXID, Preferred name, CAS number, JChem InChIKey, and Indigo InChIKey. Instructions To add a chemical associated with a particular stressor, next to the Chemical Table click ‘Add chemical.’ This will redirect you to a page entitled “New Stressor Chemical.’ The dialog box can be used to search for chemical by name, CAS number, JChem InChIKey, and Indigo InChIKey. Searching by these fields will bring forward a drop down list of existing stressor chemicals formatted as “CAS- preferred name” “JChem InChIKey – preferred name” or “Indigo InChIKey- preferred name” depending on which field you perform the search. Select an entity from the drop down list and click ‘Add chemical.’ This will return you to the Stressor Page, where the new record should be in the ‘Chemical Table’ on the page.AOP Evidence
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
Tetrabromobisphenol A (TBBPA) has been found to competitively bind to TTR (Meerts et al 2000; Weiss et al 2015) and other bisphenols have been implicated as thyroid toxicants (Boas et al 2012). Iakovleva et al (2016) recently reported the crystal structure of TTR-TBBPA
Boas, M., Feldt-Rasmussen, U., & Main, K. M. (2012). Thyroid effects of endocrine disrupting chemicals. Molecular and Cellular Endocrinology, 355(2), 240–248. http://doi.org/10.1016/j.mce.2011.09.005
Iakovleva, I., Begum, A., Brännström, K., Wijsekera, A., Nilsson, L., Zhang, J., … Olofsson, A. (2016). Tetrabromobisphenol a is an efficient stabilizer of the transthyretin tetramer. PLoS ONE, 11(4), 1–16. http://doi.org/10.1371/journal.pone.0153529
Meerts, I. a, van Zanden, J. J., Luijks, E. a, van Leeuwen-Bol, I., Marsh, G., Jakobsson, E., … Brouwer, a. (2000). Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicological Sciences : An Official Journal of the Society of Toxicology, 56(1), 95–104. http://doi.org/10.1093/toxsci/56.1.95
Weiss, J. M., Andersson, P. L., Zhang, J., Simon, E., Leonards, P. E. G., Hamers, T., & Lamoree, M. H. (2015). Tracing thyroid hormone-disrupting compounds: database compilation and structure-activity evaluation for an effect-directed analysis of sediment. Analytical and Bioanalytical Chemistry, 5625–5634. http://doi.org/10.1007/s00216-015-8736-9
Event Evidence
This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.
Stressor Info
Chemical/Category Description
Instructions To edit the “ Stressor Description” section, on a KER page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.” Scroll down to the “Stressor Description” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page. The new text should appear under the “Stressor Description” section on the page.Characterization of Exposure
Instructions To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.” Scroll down to the “Characterization of Exposure” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page. The new text should appear under the “Characterization of Exposure” section on the page.References
List the bibliographic references to original papers, books or other documents used to support the Stressor. Instructions To edit the “References” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.” Scroll down to the “References” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page. The new text should appear under the “References” section on the page.