API

Stressor: 261

Title

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Tetrabromobisphenol A

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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AOP Evidence

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Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity

Tetrabromobisphenol A (TBBPA) has been found to competitively bind to TTR (Meerts et al 2000; Weiss et al 2015) and other bisphenols have been implicated as thyroid toxicants (Boas et al 2012).  Iakovleva et al (2016) recently reported the crystal structure of TTR-TBBPA

Boas, M., Feldt-Rasmussen, U., & Main, K. M. (2012). Thyroid effects of endocrine disrupting chemicals. Molecular and Cellular Endocrinology, 355(2), 240–248. http://doi.org/10.1016/j.mce.2011.09.005

Iakovleva, I., Begum, A., Brännström, K., Wijsekera, A., Nilsson, L., Zhang, J., … Olofsson, A. (2016). Tetrabromobisphenol a is an efficient stabilizer of the transthyretin tetramer. PLoS ONE, 11(4), 1–16. http://doi.org/10.1371/journal.pone.0153529

Meerts, I. a, van Zanden, J. J., Luijks, E. a, van Leeuwen-Bol, I., Marsh, G., Jakobsson, E., … Brouwer, a. (2000). Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicological Sciences : An Official Journal of the Society of Toxicology, 56(1), 95–104. http://doi.org/10.1093/toxsci/56.1.95

Weiss, J. M., Andersson, P. L., Zhang, J., Simon, E., Leonards, P. E. G., Hamers, T., & Lamoree, M. H. (2015). Tracing thyroid hormone-disrupting compounds: database compilation and structure-activity evaluation for an effect-directed analysis of sediment. Analytical and Bioanalytical Chemistry, 5625–5634. http://doi.org/10.1007/s00216-015-8736-9

 




Event Evidence

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This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.



Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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