AOPs Including This Stressor
|Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity||Not Specified|
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
Major metabolite 3,5,6-trichloro-2-pyridinol has been reported to disrupt TH levels via TTR binding.
Zhang J, Begum A, Brännström K, Grundström C, Iakovleva I, Olofsson A, Sauer-Eriksson AE, Andersson PL. Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ Sci Technol. 2016 Nov 1;50(21):11984-11993.
Zhang, J., Kamstra, J. H., Ghorbanzadeh, M., Weiss, J. M., Hamers, T., & Andersson, P. L. (2015). In Silico Approach To Identify Potential Thyroid Hormone Disruptors among Currently Known Dust Contaminants and Their Metabolites. Environmental Science and Technology, 49(16), 10099–10107. http://doi.org/10.1021/acs.est.5b01742
This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.