API

Stressor: 265

Title

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Triclopyr

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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This table is automatically generated and lists KE’s including this stressor.



Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Triclopyr DTXSID0032497 Triclopyr 55335-06-3 REEQLXCGVXDJSQ-UHFFFAOYSA-N REEQLXCGVXDJSQ-UHFFFAOYSA-N

AOP Evidence

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Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity

Major metabolite 3,5,6-trichloro-2-pyridinol has been reported to disrupt TH levels via TTR binding.

Zhang J, Begum A, Brännström K, Grundström C, Iakovleva I, Olofsson A, Sauer-Eriksson AE, Andersson PL. Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ Sci Technol. 2016 Nov 1;50(21):11984-11993.

Zhang, J., Kamstra, J. H., Ghorbanzadeh, M., Weiss, J. M., Hamers, T., & Andersson, P. L. (2015). In Silico Approach To Identify Potential Thyroid Hormone Disruptors among Currently Known Dust Contaminants and Their Metabolites. Environmental Science and Technology, 49(16), 10099–10107. http://doi.org/10.1021/acs.est.5b01742




Event Evidence

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This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.



Stressor Info

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Chemical/Category Description

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Instructions

To edit the “ Stressor Description” section, on a KER page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Stressor Description” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Stressor Description”  section on the page.



Characterization of Exposure

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Instructions

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.



References

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List the bibliographic references to original papers, books or other documents used to support the Stressor.

Instructions

To edit the “References” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “References” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “References” section on the page.