API

Stressor: 265

Title

?

Triclopyr

Stressor Overview

?


AOPs Including This Stressor

?


Events Including This Stressor

?



Chemical Table

?

User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Triclopyr DTXSID0032497 Triclopyr 55335-06-3 REEQLXCGVXDJSQ-UHFFFAOYSA-N REEQLXCGVXDJSQ-UHFFFAOYSA-N

AOP Evidence

?


Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity

Major metabolite 3,5,6-trichloro-2-pyridinol has been reported to disrupt TH levels via TTR binding.

Zhang J, Begum A, Brännström K, Grundström C, Iakovleva I, Olofsson A, Sauer-Eriksson AE, Andersson PL. Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ Sci Technol. 2016 Nov 1;50(21):11984-11993.

Zhang, J., Kamstra, J. H., Ghorbanzadeh, M., Weiss, J. M., Hamers, T., & Andersson, P. L. (2015). In Silico Approach To Identify Potential Thyroid Hormone Disruptors among Currently Known Dust Contaminants and Their Metabolites. Environmental Science and Technology, 49(16), 10099–10107. http://doi.org/10.1021/acs.est.5b01742




Event Evidence

?


This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.



Stressor Info

?



Chemical/Category Description

?



Characterization of Exposure

?



References

?