Stressor: 279
Title
Stressor Overview
AOPs Including This Stressor
| AOP Name | Evidence |
|---|---|
| Inhibitor binding to topoisomerase II leading to infant leukaemia | Low |
Events Including This Stressor
Chemical Table
AOP Evidence
Inhibitor binding to topoisomerase II leading to infant leukaemia
Bioflavonoids
Bioflavonoids are natural polyphenolic compounds in a large variety of plant-derived food items. TopoII-mediated DNA cleavage has been linked to genistein, kaempferol, luteolin, myricetin and apigenin (Strick et al 2000; Bandele and Osheroff 2007; Azarova et al 2010; Lopez-Lazaro et al 2010), although the concentrations in in vitro studies have been quite high. It has also been demonstrated that several bioflavonoids are capable of inducing the cleavage of the MLL gene in human cell lines (Strick et al 2000; van Doorn-Khosrovani et al 2007). The in vitro effects of bioflavonoids suggested a possible link between dietary intake and infant leukemia (e.g., Azarova et al., 2010; Lanoue et al., 2010); however until now, epidemiological evidence existing to support or refute such a hypothesis is based on small studies (Ross et al 1996; Spector et al 2005).
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Bioflavonoids |
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Flavones |
luteolin, apigenin, diosmetin |
Ketron and Osheroff 2014 |
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Flavonols |
myricetin, quercetin, kaempferol, fisetin |
Ketron and Osheroff 2014 |
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Isoflavones |
Genistein |
Ketron and Osheroff 2014 |
|
Catechins |
EGCG, ECG, EGC, EC |
Ketron and Osheroff 2014 |
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Isothiocyanates |
benzyl-isothiocyanate, phenethyl-isothiocyanate, sulforaphane |
Ketron and Osheroff 2014
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Other phytochemicals |
Curcumin |
Ketron and Osheroff 2014 |