API

Stressor: 279

Title

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Bioflavonoids

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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AOP Evidence

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In-utero DNA topoisomerase II poisons leading to infant leukaemia

Bioflavonoids

Bioflavonoids are natural polyphenolic compounds in a large variety of plant-derived food items. TopoII-mediated DNA cleavage has been linked to genistein, kaempferol, luteolin, myricetin and apigenin (Strick et al 2000; Bandele and Osheroff 2007; Azarova et al 2010; Lopez-Lazaro et al 2010), although the concentrations in in vitro studies have been quite high. It has also been demonstrated that several bioflavonoids are capable of inducing the cleavage of the MLL gene in human cell lines (Strick et al 2000; van Doorn-Khosrovani et al 2007). The in vitro effects of bioflavonoids suggested a possible link between dietary intake and infant leukemia (e.g., Azarova et al., 2010; Lanoue et al., 2010); however until now, epidemiological evidence existing to support or refute such a hypothesis is based on small studies (Ross et al 1996; Spector et al 2005).

Bioflavonoids

Flavones

luteolin, apigenin, diosmetin

Ketron and Osheroff 2014

Flavonols

myricetin, quercetin, kaempferol, fisetin

Ketron and Osheroff 2014

Isoflavones

Genistein

Ketron and Osheroff 2014

Catechins

EGCG, ECG, EGC, EC

Ketron and Osheroff 2014

Isothiocyanates

benzyl-isothiocyanate, phenethyl-isothiocyanate, sulforaphane

Ketron and Osheroff 2014

 

Other phytochemicals

Curcumin

Ketron and Osheroff 2014

 




Event Evidence

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This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.



Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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