API

Stressor: 358

Title

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Isoniazid

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Isoniazid DTXSID8020755 Isoniazid 54-85-3 QRXWMOHMRWLFEY-UHFFFAOYSA-N QRXWMOHMRWLFEY-UHFFFAOYSA-N

AOP Evidence

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CYP2E1 activation and formation of protein adducts leading to neurodegeneration

There is no evidence text for this AOP




Event Evidence

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CYP2E1 Activation

Neafsey, P. et al. Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity. Journal of Toxicology and Environmental Health - Part B: Critical Reviews 12, 362–388 (2009)

Garciá-Suástegui, W. A. et al. The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain. Oxidative Medicine and Cellular Longevity 2017, (2017)

Indiana University. P450 Drug Interaction Table. Available at: http://medicine.iupui.edu/clinpharm/ddis/main-table/

 



Protein Adduct Formation

LoPachin, R. M. & DeCaprio, A. P. Protein adduct formation as a molecular mechanism in neurotoxicity. Toxicological Sciences 86, 214–225 (2005).




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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