Stressor: 4

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

17beta-Estradiol

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)	High
Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

Preferred name	DTXID	Casrn	jchem_inchi_key	indigo_inchi_key	User term
17beta-Estradiol	DTXSID0020573	50-28-2	VOXZDWNPVJITMN-ZBRFXRBCSA-N	VOXZDWNPVJITMN-ZBRFXRBCSA-N	Estradiol 17B

References

List of the literature that was cited for this prototypical stressor. More help