API

Stressor: 556

Title

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Vinclozolin

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Vinclozolin DTXSID4022361 Vinclozolin 50471-44-8 FSCWZHGZWWDELK-UHFFFAOYNA-N FSCWZHGZWWDELK-UHFFFAOYSA-N

AOP Evidence

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Event Evidence

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Impaired, Spermatogenesis

A review of androgen signaling in male fish cites several studies showing vinclozolin decreases sperm quality (Golshan et al., 2019)



Antagonism, Androgen receptor

Using the AR-CALUX reporter assay in antagonism mode, vinclozolin showed an IC50of 1.0 uM (Sonneveld et al, 2005).



decrease, male anogenital distance

Vinclozolin has been shown to cause decreased male AGD in rats following intrauterine exposure to doses between 50-200 mg/kg bw/day (Christiansen et al, 2009; Gray et al, 1994; Hass et al, 2007; Matsuura et al, 2005; Ostby et al, 1999; Schneider et al, 2011; Wolf et al, 2004).




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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