Stressor: 57
Title
Acetaminophen
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
| Event Name |
|---|
| CYP2E1 Activation |
| Activation of Cyp2E1 |
| Oxidative Stress |
| Hepatocytotoxicity |
| Induction, persistant proliferation/sustained proliferation |
Chemical Table
| User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
|---|---|---|---|---|---|
| Acetamide | DTXSID7020005 | Acetamide | 60-35-5 | DLFVBJFMPXGRIB-UHFFFAOYSA-N | DLFVBJFMPXGRIB-UHFFFAOYSA-N |
| Acetaminophen | DTXSID2020006 | Acetaminophen | 103-90-2 | RZVAJINKPMORJF-UHFFFAOYSA-N | RZVAJINKPMORJF-UHFFFAOYSA-N |
| Acetohexamide | DTXSID7020007 | Acetohexamide | 968-81-0 | VGZSUPCWNCWDAN-UHFFFAOYSA-N | VGZSUPCWNCWDAN-UHFFFAOYSA-N |
AOP Evidence
CYP2E1 activation and formation of protein adducts leading to neurodegeneration
There is no evidence text for this AOP
Event Evidence
CYP2E1 Activation
Neafsey, P. et al. Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity. Journal of Toxicology and Environmental Health - Part B: Critical Reviews 12, 362–388 (2009)
Garciá-Suástegui, W. A. et al. The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain. Oxidative Medicine and Cellular Longevity 2017, (2017)
Indiana University. P450 Drug Interaction Table. Available at: http://medicine.iupui.edu/clinpharm/ddis/main-table/
Activation of Cyp2E1
There is no evidence text for this event.
Oxidative Stress
There is no evidence text for this event.
Hepatocytotoxicity
There is no evidence text for this event.
Induction, persistant proliferation/sustained proliferation
There is no evidence text for this event.