API

Stressor: 57

Title

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Acetaminophen

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Acetamide DTXSID7020005 Acetamide 60-35-5 DLFVBJFMPXGRIB-UHFFFAOYSA-N DLFVBJFMPXGRIB-UHFFFAOYSA-N
Acetaminophen DTXSID2020006 Acetaminophen 103-90-2 RZVAJINKPMORJF-UHFFFAOYSA-N RZVAJINKPMORJF-UHFFFAOYSA-N
Acetohexamide DTXSID7020007 Acetohexamide 968-81-0 VGZSUPCWNCWDAN-UHFFFAOYSA-N VGZSUPCWNCWDAN-UHFFFAOYSA-N

AOP Evidence

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CYP2E1 activation and formation of protein adducts leading to neurodegeneration

There is no evidence text for this AOP




Event Evidence

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CYP2E1 Activation

Neafsey, P. et al. Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity. Journal of Toxicology and Environmental Health - Part B: Critical Reviews 12, 362–388 (2009)

Garciá-Suástegui, W. A. et al. The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain. Oxidative Medicine and Cellular Longevity 2017, (2017)

Indiana University. P450 Drug Interaction Table. Available at: http://medicine.iupui.edu/clinpharm/ddis/main-table/



Activation of Cyp2E1

There is no evidence text for this event.



Oxidative Stress

There is no evidence text for this event.



Hepatocytotoxicity

There is no evidence text for this event.



Induction, persistant proliferation/sustained proliferation

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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