Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 251 to 275 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
251 decreased gene expression (GO:0010467) carnitine O-palmitoyltransferase 1, liver isoform (PR:000005835) 472: Down Regulation, CPT1A
252 decreased gene expression (GO:0010467) hydroxymethylglutaryl-CoA synthase, mitochondrial (PR:000008638) 474: Down Regulation, HMGCS2
253 increased biosynthetic process (GO:0009058) triglyceride (CHEBI:17855)
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2
255 increased signaling (GO:0023052) bile acid receptor (PR:000011396) 479: Activation, NR1H4
256 increased signaling (GO:0023052) nuclear receptor subfamily 0 group B member 2 (PR:000011391) 480: Activation, SHP
257 decreased catalytic activity (GO:0003824) 17-beta-hydroxysteroid dehydrogenase 14 (PR:000008778) 482: Decreased, DHB4/HSD17B4
258 increased signaling (GO:0023052) microsomal triglyceride transfer protein large subunit MTTP (PR:000003392) 879: Activation, MTTP
259 increased gene expression (GO:0010467) apolipoprotein B-100 (PR:000004145) 880: Increased, ApoB100
260 occurrence inflammatory response (GO:0006954) 486: systemic inflammation leading to hepatic steatosis
261 increased signaling (GO:0023052) RAC-beta serine/threonine-protein kinase (PR:000003912) 484: Activation, AKT2
262 decreased ovulation (GO:0030728) 488: Decrease, Ovulation
263 decreased prostaglandin (CHEBI:26333) 685: Reduced, Prostaglandins, ovary
264 decreased reproductive process (GO:0022414) 675: Reduced, Reproductive Success
265 decreased hormone biosynthetic process (GO:0042446) testosterone (CHEBI:17347)
266 increased apoptotic process (GO:0006915)
267 decreased sperm quantity (VT:0002673) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
268 morphological change sperm (CL:0000019) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
269 abnormal anatomical structure development (GO:0048856) nervous system (UBERON:0001016) 186: Altered, Neuroanatomy
270 abnormal abnormal nervous system physiology (MP:0003633) 192: Altered, Neurophysiology
271 increased corticosterone (CHEBI:16827) 653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone
272 increased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405) 655: Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
273 increased abnormal fetal Leydig cell differentiation (MP:0013603)
274 increased Testicular dysgenesis (HP:0008715)
275 decreased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405)