Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 451 to 475 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
451 functional change lysosome (GO:0005764) 831: Disturbance, Lysosomal function
452 increased porphyrins (CHEBI:26214) 846: Accumulation, Highly carboxylated porphyrins
453 increased gene expression (GO:0010467) cytochrome P450 1A2 (PR:000006102) 850: Induction, CYP1A2/CYP1A5
454 increased gene expression (GO:0010467) cytochrome P450 1A5 (chicken) (PR:P79761) 850: Induction, CYP1A2/CYP1A5
455 decreased catalytic activity (GO:0003824) uroporphyrinogen decarboxylase (PR:000017134) 845: Inhibition, UROD
456 increased porphyria (MP:0005654) 369: Uroporphyria
457 increased uroporphyrinogen (CHEBI:27258) 844: Oxidation, Uroporphyrinogen
458 decreased regulation of intracellular pH (GO:0051453) 867: Decrease, Intracellular pH
459 increased leukocyte mediated cytotoxicity (GO:0001909) 768: Increase, Cytotoxicity
460 increased atrophy (MESH:D001284) olfactory epithelium (UBERON:0001997) 868: Increase, Tissue Degeneration, Necrosis & Atrophy
461 increased necrotic cell death (GO:0070265)
462 increased Metaplasia (MESH:D008679) 869: Increase, Respiratory or Squamous Metaplasia
463 increased neoplasm (MP:0002006) olfactory segment of nasal mucosa (UBERON:0005386) 872: Increase, Site of Contact Nasal Tumors
464 decreased signaling (GO:0023052) solute carrier family 22 member 6 (PR:000014993) 877: Inhibition, organic anion transporter 1 (OAT1)
465 increased uric acid (CHEBI:27226)
466 occurrence renal tubular necrosis (MP:0004154) 1097: Occurrence, renal proximal tubular necrosis
467 increased potassium atom (CHEBI:26216) 1098: Increased, blood potassium concentration
468 increased Arrhythmias, Cardiac (MESH:D001145) 1106: Occurrence, cardiac arrhythmia
469 increased Neoplasms (MESH:D009369) 885: Increase, Cancer
470 occurrence organelle disassembly (GO:1903008) lysosome (GO:0005764) 898: Disruption, Lysosome
471 occurrence liver inflammation (MP:0001860) 902: Inflammation, Liver
472 increased phosphorylation (GO:0016310) transcription factor Sp1 (PR:000000133) 924: Activation, Sp1
473 occurrence epidermal growth factor-activated receptor activity (GO:0005006) epidermal growth factor receptor (PR:000006933) 941: Activation, EGFR
474 decreased epithelial cell apoptotic process (GO:1904019) None
475 occurrence transdifferentiation (GO:0060290) ciliated epithelial cell (CL:0000067) 919: Occurrence, Transdifferentiation of ciliated epithelial cells