Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 601 to 625 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
541 increased cell proliferation (GO:0008283) smooth muscle cell (CL:0000192) 1042: Proliferation/Clonal Expansion, smooth muscle
540 increased relaxation of smooth muscle (GO:0044557) 1040: relaxation, smooth muscle
539 increased beta2-adrenergic receptor activity (GO:0004941) beta-2 adrenergic receptor (PR:000001193) 1039: Increased activity, beta-2 adrenergic receptor
538 increased beta-2 adrenergic receptor binding (GO:0031698) beta-2 adrenergic receptor (PR:000001193) 1038: Activation, beta-2 adrenergic receptor
537 increased hemangiosarcoma (MESH:D006394) 1037: Increased, hemagiosarcoma
536 increased liposarcoma (MESH:D008080) 1036: Increased, liposarcoma
535 increased Fibrosarcoma (MESH:D005354) 1035: Increased, Firbrosarcoma
534 increased gene expression (GO:0010467) IGF-like family receptor 1 (mouse) (PR:Q3U4N7) 1034: Increased, IGF-1 (mouse)
533 increased mesenchymal cell proliferation (GO:0010463) mesenchymal cell (CL:0008019) 1033: Increased, proliferation of mesenchymal cells
532 increased secretion (GO:0046903) eukaryotic protein (PR:000036194) 1032: Increased, secretion of local growth factors
531 increased fat cell differentiation (GO:0045444) 1029: Increased, adipogenesis
530 increased hormone catabolic process (GO:0042447) thyroxine (CHEBI:30660) 1021: Increased, T4/T3 catabolism
529 increased gene expression (GO:0010467) UDP-glucuronosyltransferase (PR:000024849) 1020: Increased, induction of UDPGT's in liver
528 decreased negative regulation of synaptic transmission (GO:0050805) GABA receptor complex (GO:1902710) 1015: Increased, Neuronal synaptic inhibition
527 increased inhibitory postsynaptic potential (GO:0060080) 1012: Increased, Inhibitory postsynaptic potential
526 decreased catalytic activity (GO:0003824) type I iodothyronine deiodinase (PR:000006480) 1009: Inhibition, Deiodinase 1
525 decreased sensory perception of sound (GO:0007605) 1008: Reduced, Hearing
524 decreased swim bladder inflation (GO:0048798) anterior chamber swim bladder (UBERON:2001277) 1007: Reduced, Anterior swim bladder inflation
523 decreased survival (MESH:D013534) None
522 decreased swim bladder inflation (GO:0048798) posterior chamber swim bladder (UBERON:2001278) 1004: Reduced, Posterior swim bladder inflation
521 decreased catalytic activity (GO:0003824) type II iodothyronine deiodinase (PR:000006481) 1002: Inhibition, Deiodinase 2
520 decreased 3,3',5-triiodo-L-thyronine (CHEBI:18258)
519 decreased interleukin-4 production (GO:0032633) interleukin-4 (PR:000001391)
518 decreased interleukin-2 production (GO:0032623) interleukin-2 (PR:000001379) 1202: Suppression, IL-2 and IL-4 production
517 increased binding (GO:0005488) Immunophilins (MESH:D020104) 1201: Binding, Immunophilins