Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 651 to 675 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
651 abnormal gene expression (GO:0010467) 1239: Altered, Gene Expression
652 abnormal translation (GO:0006412) protein (PR:000000001) 1240: Altered, Protein Production
653 increased cell motility (GO:0048870) 1241: Increased, Motility
654 increased second-messenger-mediated signaling (GO:0019932) 1242: Increased, Second Messenger Production
655 increased signaling (GO:0023052) juvenile hormone (CHEBI:24943) 1205: Activation, Juvenile hormone receptor
656 increased gene expression (GO:0010467) protein doublesex (fruit fly) (PR:P23023) 1206: Induction, Doublesex1 gene
657 increased offspring quantity (VT:1000189) 1208: Increased, Male offspring
658 increased male organism (UBERON:0003101) 1208: Increased, Male offspring
659 increased male reproductive organ (UBERON:0003135) 1209: Induction, Male reproductive tract
660 abnormal Food Chain (MESH:D020387) 1210: Alteration, Food-web structures
661 abnormal DNA topoisomerase II activity (GO:0061505) 1252: Binding to (interferes with) topoisomerase II enzyme
662 occurrence Translocation, Genetic (MESH:D014178) 1253: MLL chromosomal translocation
663 abnormal cellular component organization (GO:0016043) 1258: Decompartmentalization
664 decreased function (MI:0613) mitochondrion (GO:0005739) 1260: Direct mitochondrial inhibition
665 abnormal plasma membrane organization (GO:0007009) 1259: narcosis
666 increased signaling (GO:0023052) NADPH Oxidase (MESH:D019255) 1174: Activation, NADPH Oxidase
667 increased biosynthetic process (GO:0009058) reactive oxygen species (CHEBI:26523) None
668 increased signaling (GO:0023052) map kinase p38 (PR:000003106) 1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK
669 increased signaling (GO:0023052) hypoxia-inducible factor 1 (Caenorhabditis elegans) (PR:G5EGD2) 1280: Activation, HIF-1
670 increased DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 1281: Increased, DNA Damage-Repair
671 increased signaling (GO:0023052) Janus kinase (PR:000025748) 1282: Activation, JAK/STAT pathway
672 increased signaling (GO:0023052) signal transducer and transcription activator STAT (PR:000001933) 1282: Activation, JAK/STAT pathway
673 increased signaling (GO:0023052) TGF-beta (PR:000000046) 1283: Activation, TGF-beta pathway
674 increased gene expression (GO:0010467) sterol regulatory element-binding protein 2 proteolytic cleavage product (PR:000021564) 1284: Up Regulation, SREBF2
675 increased unsaturated fatty acid biosynthetic process (GO:0006636) unsaturated fatty acid (CHEBI:27208) 1285: Up Regulation, Unsaturated fatty acid