Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 701 to 725 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
441 increased abnormal amino acid level (MP:0005332) 813: Increased, Serum creatinine
440 increased creatinine (CHEBI:16737) 813: Increased, Serum creatinine
439 decreased function (MI:0613) kidney (UBERON:0002113) 825: Decreased, Renal ability to dilute urine
438 decreased renal absorption (GO:0070293) sodium(1+) (CHEBI:29101) 821: Decreased, Sodium reabsorption
437 decreased kidney plasma flow trait (VT:0005524) 820: Decreased, Renal plasma flow
436 decreased glomerular filtration (GO:0003094) 819: Decreased, Glomerular filtration
435 decreased signaling (GO:0023052) alpha-2A adrenergic receptor (PR:000001186) 849: Inhibition, Antgonism of NE receptor
434 decreased norepinephrine binding (GO:0051380) (R)-noradrenaline (CHEBI:18357) 848: Decreased, Binding of NE to NE receptors on GnRH neurons
433 decreased hormone secretion (GO:0046879) Luteinizing hormone (CHEBI:81568)
432 decreased reduced fertility (MP:0001921) fertility (MESH:D005298) 527: Decreased, Decreased fecundity
431 morphological change male reproductive system (UBERON:0000079) 809: malformed, Male reproductive tract
430 decreased hydroxymethylglutaryl-CoA reductase activity (GO:0042282) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (PR:000008636) 804: Inhibition, HMG-CoA reductase
429 decreased cholesterol (CHEBI:16113) None
428 decreased mevalonate (CHEBI:25350) 805: Decreased, mevalonate
427 abnormal signaling (GO:0023052) hypoxia-inducible factor 1-alpha (PR:000008555) 801: modulation, Unknown
426 increased gene expression (GO:0010467) hypoxia-inducible factor 1-alpha (PR:000008555)
425 decreased catalytic activity (GO:0003824) Prolyl hydroxylases (MESH:D064828) 798: Inhibition, Prolyl hydroxylases
424 increased gene expression (GO:0010467) hypoxia-inducible factor 1 (Caenorhabditis elegans) (PR:G5EGD2) 799: Increased, HIF-1 heterodimer
423 decreased aromatase activity (GO:0070330) aromatase isoform 1 (PR:000038849) 800: Decreased, Aromatase (Cyp19a1) mRNA
422 increased hyperplasia (MESH:D006965) urothelial cell (CL:0000731) 796: Increase, Hyperplasia (urothelial)
421 increased cell proliferation (GO:0008283) urothelial cell (CL:0000731) 795: Increase, Regenerative cell proliferation (urothelial cells)
420 increased cell death (GO:0008219) urothelial cell (CL:0000731) 794: Increase, Cytotoxicity (urothelial cells)
419 increased cystolithiasis (MP:0011625) Calculi (MESH:D002137) 793: Increase, Urinary bladder calculi
418 decreased catalytic activity (GO:0003824) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) (PR:P31214) None
417 increased increased thyroid-stimulating hormone level (MP:0005135) Thyroid stimulating hormone (CHEBI:81567) 753: Increase, Thyroid-stimulating hormone (TSH)