Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 801 to 825 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
341 decreased serotonin uptake (GO:0051610) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
340 decreased abnormal sheltering behavior (MP:0014039) 629: Decreased, sheltering
339 decreased fear/anxiety related behavior (NBO:0000018) 627: Decreased, anxiety
338 decreased serotonin secretion (GO:0001820) sodium-dependent serotonin transporter (PR:000015189) 626: Increased, serotonin (5-HT)
337 increased musculoskeletal movement (GO:0050881) valve (UBERON:0003978) 1142: Increased, valve movement
336 decreased neurotransmitter reuptake (GO:0098810) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
335 increased fossorial locomotion behavior (NBO:0000071) 624: Increased, foot detachment
334 increased locomotion (GO:0040011) 622: Increased, locomotion
333 increased membrane depolarization (GO:0051899) 599: prolonged, Depolarization of neuronal membrane
332 increased neurotransmitter secretion (GO:0007269) 600: Overactivation, Neuronotransmitter release
331 decreased potassium channel inhibitor activity (GO:0019870) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
330 decreased hypoxia (MP:0005039) 590: N/A, hypoxia
329 increased Amputation, Congenital (MESH:C565682) 591: Increased, amputations
328 decreased life span trait (VT:0005372)
327 decreased aquatic locomotion (NBO:0000371)
326 decreased action potential (GO:0001508) 585: Decreased, Sodium conductance 1
325 decreased sodium channel inhibitor activity (GO:0019871) sodium channel protein type 1 subunit alpha (PR:000002095)
324 increased predatory behavior (GO:0002120)
323 decreased receptor regulator activity (GO:0030545) 663: Desensitization, Nicotinic acetylcholine receptor
322 increased acetylcholine receptor activator activity (GO:0030549) Nicotinic acetylcholine receptor (FMA:61796) 663: Desensitization, Nicotinic acetylcholine receptor
321 abnormal calmodulin binding (GO:0005516) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
320 decreased feeding behavior (NBO:0000079)
319 decreased hydrogen peroxide biosynthetic process (GO:0050665) hydrogen peroxide (CHEBI:16240) 579: Decreased, Hydrogen peroxide production
318 decreased glucose oxidase activity (GO:0046562) D-glucono-1,5-lactone (CHEBI:16217) 578: Decreased, Glucose oxidase enzyme activity
317 abnormal developmental process (GO:0032502) 577: impaired, Development