Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 51 to 75 of 1139 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


51	decreased	chemical synaptic transmission (GO:0007268)		669: Reduction, Neuronal synaptic inhibition
52	occurrence	excitatory postsynaptic potential (GO:0060079)		682: Generation, Amplified excitatory postsynaptic potential (EPSP)
53	occurrence	seizures (NBO:0000025)		613: Occurrence, Epileptic seizure
54	decreased	calcium ion transport (GO:0006816)	calcium ion (CHEBI:39124)	2 Events 52: Decreased, Calcium influx 49: Reduction, Ca and HCO3 transport to shell gland
55	decreased	gene expression (GO:0010467)	brain-derived neurotrophic factor (PR:000004716)	381: Reduced levels of BDNF
56	decreased	secretion (GO:0046903)	brain-derived neurotrophic factor (PR:000004716)	381: Reduced levels of BDNF
57	increased	cell death (GO:0008219)		2 Events 55: Increase, Cell injury/death 768: Increase, Cytotoxicity
58	increased	neurodegeneration (MP:0002229)		352: N/A, Neurodegeneration
59	decreased	learning (GO:0007612)		341: Impairment, Learning and memory
60	abnormal	dendrite morphogenesis (GO:0048813)	dendrite (GO:0030425)	382: Aberrant, Dendritic morphology
61	decreased	glutamate secretion, neurotransmission (GO:0061535)	glutamate(1-) (CHEBI:14321)	None
62	decreased	synapse assembly (GO:0007416)	synapse (GO:0045202)	385: Decrease of synaptogenesis
63	decreased	synaptic signaling (GO:0099536)		2 Events 386: Decrease of neuronal network function 618: Decreased, Neuronal network function in adult brain
64	decreased	memory (GO:0007613)		341: Impairment, Learning and memory
65	increased	glucocorticoid receptor activity (GO:0004883)	glucocorticoid receptor (PR:000011406)	3 Events 122: Increase, Glucocorticoid receptor activation 494: Glucocorticoid Receptor Agonist, Activation 654: Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
66	decreased	I-kappaB kinase/NF-kappaB signaling (GO:0007249)	transcription factor NF-kappa-B subunit (PR:000001753)	202: Inhibition, Nuclear factor kappa B (NF-kB)
67	decreased	cytokine production involved in inflammatory response (GO:0002534)		152: Suppression, Inflammatory cytokines
68	decreased		lymphocyte (CL:0000542)	168: Decreased, Lymphocytes
69	increased	I-kappaB phosphorylation (GO:0007252)	NF-kappa-B inhibitor (PR:000003292)	145: Induction, IKB inhibitory protein
70	increased	suppression of host defenses (GO:0044414)	immune system (UBERON:0002405)	403: Suppression, Immune system
71	increased	Disease Susceptibility (MESH:D004198)		323: Increased, Disease susceptibility
72	increased	DNA alkylation (GO:0006305)	deoxyribonucleic acid (CHEBI:16991)	97: Alkylation, DNA
73	increased	mutation (MESH:D009154)	deoxyribonucleic acid (CHEBI:16991)	3 Events 185: Increase, Mutations 336: Increase, Heritable mutations in offspring 876: Increase, Mutations in Critical Genes
74	functional change	DNA repair (GO:0006281)	deoxyribonucleic acid (CHEBI:16991)	None
75	decreased	acetylcholinesterase activity (GO:0003990)	acetylcholinesterase (PR:000003626)	12: Acetylcholinesterase (AchE) Inhibition