Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 351 to 375 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
351 decreased mating pheromone secretion (GO:0071834) pheromone (CHEBI:26013) 678: Reduced, Pheromone release
352 increased 3',5'-cyclic AMP(1-) (CHEBI:58165) 693: Increased, cyclic adenosine monophosphate
353 decreased Gonadotropin Releasing Hormone (MESH:D007987) 689: Reduced, Gonadotropin releasing hormone, hypothalamus
354 decreased steroid hormone (CHEBI:26764) 691: Reduced, Maturation inducing steroid, plasma
355 decreased steroid hormone receptor activity (GO:0003707) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte
356 decreased G2/MI transition of meiotic cell cycle (GO:0008315) 694: Reduced, Meiotic prophase I/metaphase I transition, oocyte
357 abnormal chromosome segregation (GO:0007059) 696: Increased, Chromosome misseggregation
358 decreased signaling (GO:0023052) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte
359 increased deactivation of mitotic spindle assembly checkpoint (GO:1902426) MAD2 like protein (fruit fly) (PR:Q9VNE1) 695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
360 abnormal action potential (GO:0001508) 698: Altered, Action Potential
361 increased Arrhythmias, Cardiac (MESH:D001145) 699: Increased, cardiac arrthymia
362 decreased ion channel activity (GO:0005216) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 697: impaired, ion channels
363 decreased ion channel activity (GO:0005216) ATP-sensitive inward rectifier potassium channel 1 (PR:000001978) 697: impaired, ion channels
364 increased cell death (GO:0008219) kidney tubule cell (CL:1000507) 709: Increase, Cytotoxicity (renal tubular cell)
365 increased epithelial cell proliferation (GO:0050673) nephron tubule epithelial cell (CL:1000494) None
366 increased Adenoma (MESH:D000236)
367 increased Carcinoma (MESH:D002277)
368 increased hyperplasia (MESH:D006965) kidney tubule cell (CL:1000507) 767: Increase, Hyperplasia (renal tubular cells)
369 increased major urinary protein (rat) (PR:P02761) 708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
370 increased binding (GO:0005488) major urinary protein (rat) (PR:P02761) 714: Increased, Binding of chemicals to 2u (serum)
371 abnormal chromosome movement towards spindle pole (GO:0051305) chromosome (GO:0005694) 752: Altered, Meiotic chromosome dynamics
372 increased tubulin binding (GO:0015631) tubulin (PR:000028799) 718: Binding, Tubulin
373 increased microtubule depolymerization (GO:0007019) microtubule (GO:0005874) 720: Disruption, Microtubule dynamics
374 decreased spindle organization (GO:0007051) spindle (GO:0005819) 721: Disorganization, Meiotic Spindle
375 increased cell proliferation (GO:0008283) mitogenic signaling cell (CL:0000422) 716: Increase, cell proliferation (hepatocytes)