Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 776 to 800 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
776 decreased protein secretion (GO:0009306) vitellogenins (MESH:D014819) 285: Reduction, Vitellogenin synthesis in liver
777 decreased mRNA transcription (GO:0009299) aromatase (PR:000006100) 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
778 decreased protein tyrosine kinase activity (GO:0004713) tyrosine-protein kinase fyna (zebrafish) (PR:Q6EWH2) 1884: Inhibition of Fyna
779 decreased microphthalmia (MP:0001297) eye (UBERON:0000970) 1878: Decreased, Eye size
780 increased negative regulation of fibrinolysis (GO:0051918) 1866: Fibrinolysis, decreased
781 decreased negative regulation of blood coagulation (GO:0030195) 1866: Fibrinolysis, decreased
782 increased increased vascular permeability (MP:0003070) 1867: Bradykinin system, hyperactivated
783 increased vasodilation (GO:0042311) 1867: Bradykinin system, hyperactivated
784 increased vascular inflammation (MP:0001863) 1867: Bradykinin system, hyperactivated
785 morphological change retina layer formation (GO:0010842) retina (UBERON:0000966) 1877: Altered, retinal layer structure
786 decreased pattern recognition receptor signaling pathway (GO:0002221) RNA viral genome (GO:0019022) None
787 decreased type I interferon signaling pathway (GO:0060337) signalling molecule (CHEBI:62488) None
788 decreased cellular response to type I interferon (GO:0071357) type I interferon receptor complex (GO:0038197) None
789 decreased transcription, DNA-templated (GO:0006351) None
790 decreased translation (GO:0006412) None
791 decreased chloride channel activity (GO:0005254) 1906: Cystic Fibrosis Transmembrane Regulator Function, Decreased
792 decreased epithelial cilium movement (GO:0003351) None
793 decreased regulation of cilium movement (GO:0003352) None
794 decreased mucociliary clearance trait (VT:0001947) 1909: Mucociliary Clearance, Decreased
795 decreased mitochondrion (GO:0005739) None
796 decreased ATP synthesis coupled proton transport (GO:0015986) mitochondrion (GO:0005739) None
797 increased oxidative phosphorylation uncoupler activity (GO:0017077) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
798 decreased regulation of mitochondrial membrane potential (GO:0051881) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
799 increased proton binding (GO:1901691) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
800 decreased epithelial lining fluid (UBERON:0035963) 1907: Airway Surface Liquid Height, Decreased