Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 801 to 825 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
801 decreased Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) None
802 occurrence Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) 1908: Cilia Beat Frequency, Decreased
803 occurrence phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) None
804 increased translation (GO:0006412) mucin-5AC (PR:000031343) 962: Increase, Mucin production
805 increased mucus secretion (GO:0070254) lung goblet cell (CL:1000143) 1251: Chronic, Mucus hypersecretion
806 increased NLRP3 inflammasome complex assembly (GO:0044546) NLRP3 inflammasome complex (GO:0072559) 1895: NLRP3 inflammasome activity, increased
807 decreased motile cilium (GO:0031514) 1912: Motile Cilia Number/Length, Decreased
808 decreased forkhead box protein J1 (PR:000007628) 1911: FOXJ1 Protein, Decreased
809 decreased cftr isoform 1 (PR:000001045) None
810 functional change vision trait (VT:0002090) eye (UBERON:0000970) 1643: Altered, Visual function
811 increased glycosylation (GO:0070085) mucin-5AC (PR:000031343) 1910: Mucus Viscosity, Increased
812 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (human) (PR:Q9BYF1) None
813 increased regulation of peptidase activity (GO:0052547) angiotensin-converting enzyme (human) (PR:P12821) None
814 decreased angiotensin-converting enzyme 2 (PR:000003622) None
815 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
816 increased carboxypeptidase activity (GO:0004180) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
817 decreased protein localization to cell surface (GO:0034394) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
818 increased angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
819 increased phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) 941: Activation, EGFR
820 decreased apoptotic process (GO:0006915) ciliated epithelial cell (CL:0000067) 914: Decrease, Apoptosis of ciliated epithelial cells
821 increased synaptic transmission, glutamatergic (GO:0035249) None
822 increased synaptic transmission, glutamatergic (GO:0035249) glutamate(1-) (CHEBI:14321) None
823 increased synaptic transmission, glutamatergic (GO:0035249) L-glutamate(1-) (CHEBI:29985) 1350: Increased, glutamate
824 increased viral release from host cell (GO:0019076) 1939: Viral infection and host-to-host transmission, proliferated
825 abnormal otic vesicle formation (GO:0030916) 1930: altered, inner ear development