Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 826 to 850 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
826 increased chronic inflammatory response (GO:0002544) 1868: Hyperinflammation
827 increased Increased inflammatory response (HP:0012649) interleukin-6 (PR:000001393) None
828 increased Increased inflammatory response (HP:0012649) tumor necrosis factor alpha (PR:000000134) None
829 increased Increased inflammatory response (HP:0012649) interleukin-1 beta (PR:000001136) None
830 increased regulation of chronic inflammatory response (GO:0002676) 1868: Hyperinflammation
831 increased interleukin-6 production (GO:0032635) interleukin-6 (PR:000001393) 1868: Hyperinflammation
832 increased interleukin-1 beta production (GO:0032611) interleukin-1 beta (PR:000001136) 1868: Hyperinflammation
833 increased tumor necrosis factor secretion (GO:1990774) tumor necrosis factor alpha (PR:000000134) 1868: Hyperinflammation
834 increased Increased inflammatory response (HP:0012649) 1868: Hyperinflammation
835 increased Increased serum ferritin (HP:0003281) Ferritin (CHEBI:82594) 1868: Hyperinflammation
836 increased lactate dehydrogenase activity (GO:0004457) 1868: Hyperinflammation
837 increased Elevated C-reactive protein level (HP:0011227) C-reactive protein (PR:000005897) 1868: Hyperinflammation
838 decreased Lymphopenia (HP:0001888) lymphocyte (CL:0000542) 1868: Hyperinflammation
839 disrupted barrier epithelial cell (CL:0000073) 1931: Intestinal barrier, disruption
840 increased luteinizing hormone signaling pathway (GO:0042700) None
841 increased increased luteinizing hormone level (MP:0005133) steroidogenic factor 1 (PR:000011411) None
842 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 3 (PR:000015718) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
843 increased estrogen secretion (GO:0035937) Estrogen (FMA:83376) 1973: Increased, estrogens
844 increased StAR-related lipid transfer protein 4 (human) (PR:Q96DR4) None
845 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 4 (PR:000015719) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
846 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 5 (PR:000015720) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
847 increased increased luteinizing hormone level (MP:0005133) StAR-related lipid transfer protein 6 (PR:000015721) 1972: Increased, Steroidogenic acute regulatory protein (StAR)
848 increased transmembrane protease serine 2 (human) (PR:O15393) None
849 increased neuropilin binding (GO:0038191) neuropilin-1 (PR:000001900) None
850 increased protease binding (GO:0002020) transmembrane protease serine 2 (human) (PR:O15393) None