Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 851 to 875 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
851 disrupted action potential (GO:0001508) 1983: Disruption, action potential generation
852 increased Cytokine (FMA:84050) None
853 increased cytokine production involved in inflammatory response (GO:0002534) Cytokine (FMA:84050) 1496: Increased, secretion of proinflammatory mediators
854 increased chemokine secretion (GO:0090195) Chemokine (FMA:241981) 1496: Increased, secretion of proinflammatory mediators
855 increased complement activation (GO:0006956) 1496: Increased, secretion of proinflammatory mediators
856 increased Interleukin (FMA:86578) 1496: Increased, secretion of proinflammatory mediators
857 increased inflammatory response (GO:0006954) inflammatory cell (CL:0009002) 1497: Increased, recruitment of inflammatory cells
858 increased macrophage activation (GO:0042116) macrophage (CL:0000235) 1497: Increased, recruitment of inflammatory cells
859 increased neutrophil activation (GO:0042119) neutrophil (CL:0000775) None
860 increased DNA damage response, detection of DNA damage (GO:0042769) site of DNA damage (GO:0090734)
861 increased mutation (MESH:D009154) 1669: Increased, DNA damage and mutation
862 increased chromosome breakage (GO:0031052) chromosome (GO:0005694)
863 increased chromosomal instability (MP:0008866) chromosome (GO:0005694)
864 increased abnormal DNA repair (MP:0008058) DNA repair complex (GO:1990391) 1669: Increased, DNA damage and mutation
865 increased cell proliferation (GO:0008283) mesothelial cell (CL:0000077) 870: Increase, Cell Proliferation
866 increased Neoplasm of the lung (HP:0100526) lung (UBERON:0002048) 1670: Lung cancer
867 increased increased lung tumor incidence (MP:0008014) lung (UBERON:0002048) 1670: Lung cancer
868 increased pattern recognition receptor signaling pathway (GO:0002221) 1495: Substance interaction with the lung resident cell membrane components
869 increased toll-like receptor signaling pathway (GO:0002224) Toll-like receptor (PR:000001096) 1495: Substance interaction with the lung resident cell membrane components
870 increased toll-like receptor 4 signaling pathway (GO:0034142) Toll-like receptor 4 (PR:000001155) 1495: Substance interaction with the lung resident cell membrane components
871 increased Malignant mesothelioma (HP:0100001) mesothelioma (MESH:D008654) 1090: Increased, mesotheliomas
872 occurrence receptor binding (GO:0005102) angiotensin-converting enzyme 2 (PR:000003622) 1739: Binding to ACE2
873 occurrence endocytosis involved in viral entry into host cell (GO:0075509) host cell membrane (GO:0033644) None
874 occurrence protease binding (GO:0002020) transmembrane protease serine 2 (PR:000016456) None
875 occurrence membrane fusion (GO:0061025) host cell membrane (GO:0033644) None