Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 876 to 900 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
876 occurrence membrane fusion (GO:0061025) transmembrane protease serine 2 (PR:000016456) 1738: SARS-CoV-2 cell entry
877 occurrence endocytosis involved in viral entry into host cell (GO:0075509) cathepsin L1 (human) (PR:P07711) 1738: SARS-CoV-2 cell entry
878 decreased type I interferon signaling pathway (GO:0060337) interferon alpha (PR:000024938) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
879 decreased type I interferon signaling pathway (GO:0060337) interferon beta (PR:000024939) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
880 occurrence cellular response to exogenous dsRNA (GO:0071360) RNA viral genome (GO:0019022) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
881 decreased receptor antagonist activity (GO:0048019) smoothened homolog (human) (PR:Q99835) None
882 decreased smoothened (PR:000015288) None
883 decreased regulation of receptor activity (GO:0010469) smoothened (PR:000015288) 2027: Antagonism, Smoothened receptor
884 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI1 (human) (PR:P08151) None
885 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI1 (PR:000008026) 2028: Decrease, GLI1/2 translocation to nucleus
886 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI2 (PR:000008027) 2028: Decrease, GLI1/2 translocation to nucleus
887 increased gene expression (GO:0010467)
888 decreased gene expression (GO:0010467)
889 decreased gene expression (GO:0010467) zinc finger protein GLI1 (PR:000008026) 2040: Decrease, GLI1/2 target gene expression
890 decreased gene expression (GO:0010467) zinc finger protein GLI2 (PR:000008027) 2040: Decrease, GLI1/2 target gene expression
891 decreased secondary palatal shelf (UBERON:0005619) None
892 decreased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) None
893 decreased abnormal palatal shelf fusion at midline (MP:0009887) secondary palate (UBERON:0001716) None
894 increased Cleft palate (HP:0000175) 2042: Increase, Orofacial clefting
895 increased cleft upper lip (MP:0005170) 2042: Increase, Orofacial clefting
896 decreased second-messenger-mediated signaling (GO:0019932) None
897 decreased protein localization to cilium (GO:0061512) smoothened (PR:000015288) 2044: Decrease, Smoothend relocation and activation
898 decreased decreased triiodothyronine level (MP:0005473) 3,3',5'-triiodothyronine (CHEBI:28774) 1003: Decreased, Triiodothyronine (T3)
899 occurrence Blood vessel (FMA:63183) None
900 occurrence blood vessel remodeling (GO:0001974) blood vessel (UBERON:0001981) 2069: Occurrence, Abnormal Vascular Remodeling