Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 901 to 925 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
901 functional change nitric oxide homeostasis (GO:0033484) endothelium (UBERON:0001986) 2067: Altered, Nitric Oxide Levels
902 increased eye opacity (MP:0009859) Lens (FMA:58241) 2083: Occurrence of Cataracts
903 decreased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 1702: Suppression of T cell activation
904 increased goblet cell (CL:0000160) 2117: Increase, goblet cell number
905 increased endocrine signaling (GO:0038002) estrone (CHEBI:17263) 2092: Promotion, Ovarian Cancer
906 decreased sonic hedgehog protein (PR:000014841) None
907 decreased second-messenger-mediated signaling (GO:0019932) sonic hedgehog protein (PR:000014841) 2043: Decrease, Sonic Hedgehog second messenger production
908 occurrence viral entry into host cell (GO:0046718) viral genome (GO:0019015) 1738: SARS-CoV-2 cell entry
909 occurrence viral entry into host cell (GO:0046718) viral protein (PR:000036197) 1738: SARS-CoV-2 cell entry
910 increased glutathione binding (GO:0043295) glutathione conjugate (CHEBI:24335) 2131: Conjugation, GSH
911 decreased abnormal glutathione level (MP:0012603) glutathione (CHEBI:16856) 130: Depletion, GSH
912 occurrence abnormal blood coagulation (MP:0002551) blood (UBERON:0000178) 1845: Coagulation
913 decreased fibrinolysis (GO:0042730) Fibrin (CHEBI:5054) None
914 decreased fibrinolysis (GO:0042730) 1846: Thrombosis and Disseminated Intravascular Coagulation
915 increased blood coagulation, fibrin clot formation (GO:0072378) Fibrin (CHEBI:5054) 1846: Thrombosis and Disseminated Intravascular Coagulation
916 decreased succinate dehydrogenase activity (GO:0000104) 2118: Succinate dehydrogenase, inhibited
917 decreased FAD metabolic process (GO:0046443) succinate dehydrogenase complex (GO:0045281) 2118: Succinate dehydrogenase, inhibited
918 decreased succinate metabolic process (GO:0006105) succinate dehydrogenase complex (GO:0045281) 2118: Succinate dehydrogenase, inhibited
919 increased respiratory electron transport chain (GO:0022904) superoxide (CHEBI:18421) 2120: Superoxide generation, increased
920 increased Insulin resistance (HP:0000855) 2119: Increase, Insulin resistance
921 increased kinase activity (GO:0016301) astrocyte (CL:0000127) 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
922 increased calcium amount (VT:0010499) calcium(2+) (CHEBI:29108) 1339: Increase, intracellular calcium
923 decreased signaling (GO:0023052) neurotransmitter (CHEBI:25512) 2151: Disruption, neurotransmitter release
924 functional change blood vessel endothelial cell (CL:0000071) 2096: Occurrence, (Micro)vascular dysfunction
925 functional change pericyte cell (CL:0000669) 2096: Occurrence, (Micro)vascular dysfunction