Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 551 to 575 of 1159 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
609 increased catalytic activity (GO:0003824) beta-1,3-glucuronyltransferase (PR:000001325) 295: Induction, Upregulation of glucuronyltransferase activity
608 increased transport (GO:0006810) thyroid hormone (CHEBI:60311) 1158: Increased, Hepatic thyroid hormone uptake/transport
607 increased signaling (GO:0023052) protein (PR:000000001) 1157: Activation, Hepatic nuclear receptor(s)
606 decreased catalytic activity (GO:0003824) dual oxidase 1 (PR:000006727) 1156: Inhibition, Dual oxidase
605 decreased signaling (GO:0023052) pendrin (PR:000015039) 1155: Inhibition, Pendrin
604 decreased catalytic activity (GO:0003824) type III iodothyronine deiodinase (PR:000006482) 1153: Inhibition, Deiodinase 3
603 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (human) (PR:Q6PHW0) 1152: Inhibition, Iodotyrosine deiodinase (IYD)
602 decreased carboxylation reaction (MI:1139) matrix Gla protein (mouse) (PR:P19788) 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
601 abnormal post-translational protein modification (GO:0043687) osteocalcin (PR:000030444) 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
600 increased vascular calcification (MESH:D061205) vasculature (UBERON:0002049) 1151: Osteoporosis and vascular calcification, Bone deterioration
599 increased osteoporosis (MP:0000066) 1151: Osteoporosis and vascular calcification, Bone deterioration
598 increased oxidative phosphorylation uncoupler activity (GO:0017077) 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
597 decreased wellness/fitness trait (VT:1000152) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
596 functional change organ (UBERON:0000062) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
595 increased hypovolemia (MP:0010128) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
594 increased acidosis (MP:0003031) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
593 decreased catalytic activity (GO:0003824) Vitamin K Epoxide Reductases (MESH:D064417) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
592 decreased signaling (GO:0023052) androgen receptor (PR:000004191) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
591 abnormal vitamin K metabolic process (GO:0042373) vitamin K (CHEBI:28384) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
590 decreased hemostasis (GO:0007599) 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
589 decreased blood coagulation factors (MESH:D001779) 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
588 occurrence anemia (MP:0001577) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
587 abnormal cellular detoxification (GO:1990748) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
586 decreased transport (GO:0006810) nutrient (CHEBI:33284) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
585 decreased carboxylation reaction (MI:1139) coagulation factor X (mouse) (PR:O88947) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)