Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 801 to 825 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
352 increased 3',5'-cyclic AMP(1-) (CHEBI:58165) 693: Increased, cyclic adenosine monophosphate
351 decreased mating pheromone secretion (GO:0071834) pheromone (CHEBI:26013) 678: Reduced, Pheromone release
350 decreased reproduction (GO:0000003)
349 decreased attraction-related behavior (NBO:0000280) 674: Reduced, Ability to attract spawning mates
348 abnormal fertility (MESH:D005298) 673: Reduced, Spawning behavior
347 decreased prostaglandin biosynthetic process (GO:0001516) prostaglandin F2alpha (CHEBI:15553)
346 decreased prostaglandin F2alpha (CHEBI:15553)
345 increased anesthesia (MESH:D000758) 634: N/A, sedation
344 decreased locomotion (GO:0040011) 635: Decreased, locomotion
343 decreased rhythmic excitation (GO:0043179) histaminergic neuron (CL:0011110) 633: Decrease, histaminergic neuron excitation
342 decreased histamine receptor activity (GO:0004969) histamine H2 receptor (PR:000001423) 638: Antagonism, Histamine Receptor (H2)
341 decreased serotonin uptake (GO:0051610) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
340 decreased abnormal sheltering behavior (MP:0014039) 629: Decreased, sheltering
339 decreased fear/anxiety related behavior (NBO:0000018) 627: Decreased, anxiety
338 decreased serotonin secretion (GO:0001820) sodium-dependent serotonin transporter (PR:000015189) 626: Increased, serotonin (5-HT)
337 increased musculoskeletal movement (GO:0050881) valve (UBERON:0003978) 1142: Increased, valve movement
336 decreased neurotransmitter reuptake (GO:0098810) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
335 increased fossorial locomotion behavior (NBO:0000071) 624: Increased, foot detachment
334 increased locomotion (GO:0040011) 622: Increased, locomotion
333 increased membrane depolarization (GO:0051899) 599: prolonged, Depolarization of neuronal membrane
332 increased neurotransmitter secretion (GO:0007269) 600: Overactivation, Neuronotransmitter release
331 decreased potassium channel inhibitor activity (GO:0019870) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
330 decreased hypoxia (MP:0005039) 590: N/A, hypoxia
329 increased Amputation, Congenital (MESH:C565682) 591: Increased, amputations
328 decreased life span trait (VT:0005372)