Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 876 to 900 of 1159 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
284 decreased regulation of steroid biosynthetic process (GO:0050810) 647: Decreased, steroidogenic protein expression
283 decreased steroid biosynthetic process (GO:0006694) 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
282 decreased intracellular cholesterol transport (GO:0032367) cholesterol (CHEBI:16113) 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
281 decreased lipoprotein transport (GO:0042953) lipoprotein (CHEBI:6495) 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins
280 decreased cholesterol biosynthetic process (GO:0006695) cholesterol (CHEBI:16113)
279 abnormal fetal proteins (MESH:D005326) 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
278 increased estrogen receptor (PR:000007204) 658: Decreased testosterone by the fetal Leydig cells, Increased estradiol
277 decreased sperm (CL:0000019)
276 increased abnormal adult Leydig cell differentiation (MP:0013604) 541: Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
275 decreased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405)
274 increased Testicular dysgenesis (HP:0008715)
273 increased abnormal fetal Leydig cell differentiation (MP:0013603)
272 increased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405) 655: Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
271 increased corticosterone (CHEBI:16827) 653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone
270 abnormal abnormal nervous system physiology (MP:0003633) 192: Altered, Neurophysiology
269 abnormal anatomical structure development (GO:0048856) nervous system (UBERON:0001016) 186: Altered, Neuroanatomy
268 morphological change sperm (CL:0000019) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
267 decreased sperm quantity (VT:0002673) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
266 increased apoptotic process (GO:0006915)
265 decreased hormone biosynthetic process (GO:0042446) testosterone (CHEBI:17347)
264 decreased reproductive process (GO:0022414) 675: Reduced, Reproductive Success
263 decreased prostaglandin (CHEBI:26333) 685: Reduced, Prostaglandins, ovary
262 decreased ovulation (GO:0030728) 488: Decrease, Ovulation
261 increased signaling (GO:0023052) RAC-beta serine/threonine-protein kinase (PR:000003912) 484: Activation, AKT2
260 occurrence inflammatory response (GO:0006954) 486: systemic inflammation leading to hepatic steatosis