Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 1076 to 1100 of 1141 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


66	decreased	I-kappaB kinase/NF-kappaB signaling (GO:0007249)	transcription factor NF-kappa-B subunit (PR:000001753)	202: Inhibition, Nuclear factor kappa B (NF-kB)
65	increased	glucocorticoid receptor activity (GO:0004883)	glucocorticoid receptor (PR:000011406)	3 Events 122: Increase, Glucocorticoid receptor activation 494: Glucocorticoid Receptor Agonist, Activation 654: Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
64	decreased	memory (GO:0007613)		341: Impairment, Learning and memory
63	decreased	synaptic signaling (GO:0099536)		2 Events 386: Decrease of neuronal network function 618: Decreased, Neuronal network function in adult brain
62	decreased	synapse assembly (GO:0007416)	synapse (GO:0045202)	385: Decrease of synaptogenesis
61	decreased	glutamate secretion, neurotransmission (GO:0061535)	glutamate(1-) (CHEBI:14321)	None
60	abnormal	dendrite morphogenesis (GO:0048813)	dendrite (GO:0030425)	382: Aberrant, Dendritic morphology
59	decreased	learning (GO:0007612)		341: Impairment, Learning and memory
58	increased	neurodegeneration (MP:0002229)		352: N/A, Neurodegeneration
57	increased	cell death (GO:0008219)		2 Events 55: Increase, Cell injury/death 768: Increase, Cytotoxicity
56	decreased	secretion (GO:0046903)	brain-derived neurotrophic factor (PR:000004716)	381: Reduced levels of BDNF
55	decreased	gene expression (GO:0010467)	brain-derived neurotrophic factor (PR:000004716)	381: Reduced levels of BDNF
54	decreased	calcium ion transport (GO:0006816)	calcium ion (CHEBI:39124)	2 Events 52: Decreased, Calcium influx 49: Reduction, Ca and HCO3 transport to shell gland
53	occurrence	seizures (NBO:0000025)		613: Occurrence, Epileptic seizure
52	occurrence	excitatory postsynaptic potential (GO:0060079)		682: Generation, Amplified excitatory postsynaptic potential (EPSP)
51	decreased	chemical synaptic transmission (GO:0007268)		669: Reduction, Neuronal synaptic inhibition
50	occurrence	membrane depolarization (GO:0051899)		616: Occurrence, A paroxysmal depolarizing shift
49	decreased	GABA-gated chloride ion channel activity (GO:0022851)	chloride (CHEBI:17996)	2 Events 64: Reduction, Ionotropic GABA receptor chloride channel conductance 762: Activation, ionotropic GABA Receptor chloride channel
48	increased	GABA receptor binding (GO:0050811)	gamma-aminobutyric acid receptor subunit alpha-6 (PR:000007771)	667: Binding at picrotoxin site, iGABAR chloride channel
47	increased	GABA receptor binding (GO:0050811)	gamma-aminobutyric acid receptor subunit alpha-5 (PR:000007770)	667: Binding at picrotoxin site, iGABAR chloride channel
46	increased	GABA receptor binding (GO:0050811)	gamma-aminobutyric acid receptor subunit alpha-1 (PR:000007766)	667: Binding at picrotoxin site, iGABAR chloride channel
45	increased	cochlear degeneration (MP:0000032)		319: Loss, Cochlear function
44	abnormal	chemical synaptic transmission (GO:0007268)		None
43	morphological change		hippocampal formation (UBERON:0002421)	None
42	abnormal	regulation of gene expression (GO:0010468)	hippocampal formation (UBERON:0002421)	756: Hippocampal gene expression, Altered