API

Aop: 241

AOP Title

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Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis

Short name:

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Latent TGFbeta1 activation leads to pulmonary fibrosis

Authors

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Point of Contact

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Marvin Martens

Contributors

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  • Marvin Martens

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on August 16, 2017 07:53

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Revision dates for related pages

Page Revision Date/Time
Increase, Differentiation of fibroblasts July 26, 2017 19:10
Induction, Epithelial Mesenchymal Transition July 26, 2017 19:11
Accumulation, Collagen September 16, 2017 10:14
Pulmonary fibrosis July 26, 2017 19:13
Activation, Latent Transforming Growth Factor Beta 1 August 16, 2017 07:50
Activation, Transforming Growth Factor beta pathway August 16, 2017 07:55
Accumulation, Collagen leads to Pulmonary fibrosis July 26, 2017 19:19
TGFbeta1 activation leads to TGFbeta pathway activation August 16, 2017 07:56
TGFbeta pathway activation leads to Differentiation of fibroblasts August 16, 2017 07:57
TGFbeta pathway activation leads to EMT August 16, 2017 07:58
Differentiation of fibroblasts leads to Accumulation, Collagen August 16, 2017 07:59
EMT leads to Accumulation, Collagen August 16, 2017 07:59
Carbon nanotubes August 09, 2017 08:03

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Name Evidence Term
Carbon nanotubes Strong

Molecular Initiating Event

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Title Short name
Activation, Latent Transforming Growth Factor Beta 1 TGFbeta1 activation

Key Events

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Title Short name
Increase, Differentiation of fibroblasts Differentiation of fibroblasts
Induction, Epithelial Mesenchymal Transition EMT
Accumulation, Collagen Accumulation, Collagen
Activation, Transforming Growth Factor beta pathway TGFbeta pathway activation

Adverse Outcome

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Title Short name
Pulmonary fibrosis Pulmonary fibrosis

Relationships Between Two Key Events (Including MIEs and AOs)

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Title Directness Evidence Quantitative Understanding
Accumulation, Collagen leads to Pulmonary fibrosis Directly leads to Strong
TGFbeta1 activation leads to TGFbeta pathway activation Directly leads to Strong
TGFbeta pathway activation leads to Differentiation of fibroblasts Directly leads to Strong
TGFbeta pathway activation leads to EMT Directly leads to Strong
Differentiation of fibroblasts leads to Accumulation, Collagen Directly leads to Strong
EMT leads to Accumulation, Collagen Directly leads to Strong

Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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[1] Ehrhart F, Nymark P, Rieswijk L, Hanspers K, Mélius J: Lung fibrosis (Homo sapiens), http://wikipathways.org/index.php/Pathway:WP3624

[2] Vietti, G., Lison, D., & van den Brule, S. (2015). Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP). Particle and Fibre Toxicology, 13(1), 11. https://doi.org/10.1186/s12989-016-0123-y

[3] Labib, S., Williams, A., Yauk, C. L., Nikota, J. K., Wallin, H., Vogel, U., & Halappanavar, S. (n.d.). Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes. https://doi.org/10.1186/s12989-016-0125-9