API XML

Aop: 241

AOP Title

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Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis

Short name:

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Latent TGFbeta1 activation leads to pulmonary fibrosis

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Marvin Martens   (email point of contact)

Contributors

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  • Marvin Martens

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on August 16, 2017 07:53

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Revision dates for related pages

Page Revision Date/Time
Increase, Differentiation of fibroblasts July 26, 2017 19:10
Induction, Epithelial Mesenchymal Transition July 26, 2017 19:11
Accumulation, Collagen September 16, 2017 10:14
Pulmonary fibrosis January 16, 2018 09:23
Activation, Latent Transforming Growth Factor Beta 1 August 16, 2017 07:50
Activation, Transforming Growth Factor beta pathway August 16, 2017 07:55
Accumulation, Collagen leads to Pulmonary fibrosis July 26, 2017 19:19
TGFbeta1 activation leads to TGFbeta pathway activation August 16, 2017 07:56
TGFbeta pathway activation leads to Differentiation of fibroblasts August 16, 2017 07:57
TGFbeta pathway activation leads to EMT August 16, 2017 07:58
Differentiation of fibroblasts leads to Accumulation, Collagen August 16, 2017 07:59
EMT leads to Accumulation, Collagen August 16, 2017 07:59
Carbon nanotubes August 09, 2017 08:03

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1468 Activation, Latent Transforming Growth Factor Beta 1 TGFbeta1 activation
2 KE 1456 Increase, Differentiation of fibroblasts Differentiation of fibroblasts
3 KE 1457 Induction, Epithelial Mesenchymal Transition EMT
4 KE 68 Accumulation, Collagen Accumulation, Collagen
5 KE 1469 Activation, Transforming Growth Factor beta pathway TGFbeta pathway activation
6 AO 1458 Pulmonary fibrosis Pulmonary fibrosis

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Accumulation, Collagen leads to Pulmonary fibrosis adjacent High
TGFbeta1 activation leads to TGFbeta pathway activation adjacent High
TGFbeta pathway activation leads to Differentiation of fibroblasts adjacent High
TGFbeta pathway activation leads to EMT adjacent High
Differentiation of fibroblasts leads to Accumulation, Collagen adjacent High
EMT leads to Accumulation, Collagen adjacent High

Network View

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Stressors

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Name Evidence Term
Carbon nanotubes High

Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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[1] Ehrhart F, Nymark P, Rieswijk L, Hanspers K, Mélius J: Lung fibrosis (Homo sapiens), http://wikipathways.org/index.php/Pathway:WP3624

[2] Vietti, G., Lison, D., & van den Brule, S. (2015). Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP). Particle and Fibre Toxicology, 13(1), 11. https://doi.org/10.1186/s12989-016-0123-y

[3] Labib, S., Williams, A., Yauk, C. L., Nikota, J. K., Wallin, H., Vogel, U., & Halappanavar, S. (n.d.). Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes. https://doi.org/10.1186/s12989-016-0125-9