API XML

Aop: 71

AOP Title

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Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation

Short name:

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Decreased Adult Testosterone 2

Graphical Representation

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Click to download graphical representation template

Authors

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Gary Klinefelter and Susan Laws

Point of Contact

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Gary Klinefelter   (email point of contact)

Contributors

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  • Gary Klinefelter

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells September 16, 2017 10:15
Decreased sperm quantity or quality in the adult, Decreased fertility December 03, 2016 16:37
Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid December 03, 2016 16:37
Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells December 03, 2016 16:37
Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 650 Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
2 KE 525 Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
3 KE 651 Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testostero
4 KE 652 Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig
5 AO 520 Decreased sperm quantity or quality in the adult, Decreased fertility Decreased sperm quantity or quality in the adult, Decreased fertility

Relationships Between Two Key Events
(Including MIEs and AOs)

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Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature High

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus High NCBI
Homo sapiens Homo sapiens High NCBI

Sex Applicability

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Sex Evidence
Male High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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