API

Aop: 71

AOP Title

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Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation

Short name:

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Decreased Adult Testosterone 2

Authors

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Gary Klinefelter and Susan Laws

Point of Contact

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Gary Klinefelter

Contributors

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  • Gary Klinefelter

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells September 16, 2017 10:15
Decreased sperm quantity or quality in the adult, Decreased fertility December 03, 2016 16:37
Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid December 03, 2016 16:37
Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells December 03, 2016 16:37
Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid

Key Events

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Title Short name
Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testostero
Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig

Adverse Outcome

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Title Short name
Decreased sperm quantity or quality in the adult, Decreased fertility Decreased sperm quantity or quality in the adult, Decreased fertility

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus Strong NCBI
Homo sapiens Homo sapiens Strong NCBI

Sex Applicability

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Sex Evidence
Male Strong

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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