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ID Title Event Component Count Biological Organization Created At Last Updated AOPs
2253 Gluten-reactive T cell receptors, generation
1 Molecular Aug 13, 2024 Jan 5, 2025 524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2278 Increased LMNA Mutation
0 Molecular Nov 20, 2024 Dec 2, 2024 550: Increased LMNA gene mutation leading to heart failure
2362 Redox cycling of a chemical by mitochondria
0 Molecular Sep 5, 2025 Oct 3, 2025 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
2363 Elevated mitochondrial ROS and dysfunction
1 Cellular Sep 5, 2025 Oct 3, 2025
2451 Increase, TDP-43 aggregation
0 Cellular Sep 6, 2026 Sep 6, 2026 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)