API

Stressor: 163

Title

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Tacrolimus

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Tacrolimus DTXSID5046354 Tacrolimus 104987-11-3 QJJXYPPXXYFBGM-LFZNUXCKSA-N QJJXYPPXXYFBGM-LFZNUXCKSA-N

AOP Evidence

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Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response

There is no evidence text for this AOP




Event Evidence

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Binding, Immunophilins

There is no evidence text for this event.



Interference, nuclear localization of NFAT

There is no evidence text for this event.



Reduction, NFAT/AP-1 complex formation

There is no evidence text for this event.



Suppression, IL-2 and IL-4 production

There is no evidence text for this event.



Impairment, T-cell dependent antibody response

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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