API

Stressor: 249

Title

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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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The Chemical Table lists chemicals associated with a stressor. This table contains information about the User’s term for a chemical, the DTXID, Preferred name, CAS number, JChem InChIKey, and Indigo InChIKey.

Instructions

To add a chemical associated with a particular stressor, next to the Chemical Table click ‘Add chemical.’ This will redirect you to a page entitled “New Stressor Chemical.’ The dialog box can be used to search for chemical by name, CAS number, JChem InChIKey, and Indigo InChIKey. Searching by these fields will bring forward a drop down list of existing stressor chemicals formatted as “CAS- preferred name” “JChem InChIKey – preferred name” or “Indigo InChIKey- preferred name” depending on which field you perform the search. Select an entity from the drop down list and click ‘Add chemical.’ This will return you to the Stressor Page, where the new record should be in the ‘Chemical Table’ on the page.


AOP Evidence

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AhR activation leading to early life stage mortality

  • The AhR is activated by numerous planar aromatic hydrocarbons. Specifically, chemicals with molecular dimensions of 12 Å x 14 Å x 5 Å are potential ligands of the AhR (Waller & McKinney 1992; 1995).
  • However, the AhR is best known as the molecular target of dioxin-like compounds (DLCs). DLCs include polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and planar polychlorinated biphenyls (PCBs). A total of seven PCDDs, ten PCDFs, and 12 PCBs are considered 'dioxin-like' because they bind to the AhR with relatively great affinity (Denison & Heath-Pagliuso 1998; Van den Berg et al 1998).
  • The prototypical and most potent DLC is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).




Event Evidence

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Altered, Cardiovascular development/function

There is no evidence text for this event.



dimerization, AHR/ARNT

There is no evidence text for this event.



Increase, COX-2 expression

There is no evidence text for this event.



Increased, Mortality

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Instructions

To edit the “ Stressor Description” section, on a KER page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Stressor Description” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Stressor Description”  section on the page.



Characterization of Exposure

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Instructions

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.



References

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List the bibliographic references to original papers, books or other documents used to support the Stressor.

Instructions

To edit the “References” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “References” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “References” section on the page.