API

Stressor: 249

Title

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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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AOP Evidence

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AhR activation leading to early life stage mortality

  • The AhR is activated by numerous planar aromatic hydrocarbons. Specifically, chemicals with molecular dimensions of 12 Å x 14 Å x 5 Å are potential ligands of the AhR (Waller & McKinney 1992; 1995).
  • However, the AhR is best known as the molecular target of dioxin-like compounds (DLCs). DLCs include polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and planar polychlorinated biphenyls (PCBs). A total of seven PCDDs, ten PCDFs, and 12 PCBs are considered 'dioxin-like' because they bind to the AhR with relatively great affinity (Denison & Heath-Pagliuso 1998; Van den Berg et al 1998).
  • The prototypical and most potent DLC is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).




Event Evidence

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Altered, Cardiovascular development/function

There is no evidence text for this event.



dimerization, AHR/ARNT

There is no evidence text for this event.



Increase, COX-2 expression

There is no evidence text for this event.



Increased, Mortality

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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