Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 276 to 300 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
276 increased abnormal adult Leydig cell differentiation (MP:0013604) 541: Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
277 decreased sperm (CL:0000019)
278 increased estrogen receptor (PR:000007204) 658: Decreased testosterone by the fetal Leydig cells, Increased estradiol
279 abnormal fetal proteins (MESH:D005326) 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
280 decreased cholesterol biosynthetic process (GO:0006695) cholesterol (CHEBI:16113)
281 decreased lipoprotein transport (GO:0042953) lipoprotein (CHEBI:6495) 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins
282 decreased intracellular cholesterol transport (GO:0032367) cholesterol (CHEBI:16113) 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
283 decreased steroid biosynthetic process (GO:0006694) 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
284 decreased regulation of steroid biosynthetic process (GO:0050810) 647: Decreased, steroidogenic protein expression
285 increased apoptotic process (GO:0006915) Leydig cell (CL:0000178) 648: Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
286 abnormal cytoskeleton organization (GO:0007010) Leydig cell (CL:0000178) 649: Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
287 increased glucocorticoid biosynthetic process (GO:0006704) glucocorticoid (CHEBI:24261) 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
288 abnormal glucocorticoid receptor activity (GO:0004883) glucocorticoid receptor (PR:000011406) 651: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
289 abnormal regulation of steroid biosynthetic process (GO:0050810) 652: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
290 decreased dopamine beta-monooxygenase activity (GO:0004500) dopamine beta-hydroxylase (PR:000006294) 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase
291 decreased norepinephrine biosynthetic process (GO:0042421) (R)-noradrenaline (CHEBI:18357) 528: Decreased, Synthesis of NE
292 decreased signaling (GO:0023052) proto-oncogene c-Fos (mouse) (PR:P01101) 529: Decreased, GnRH cfos activity
293 decreased hormone secretion (GO:0046879) Gonadotropin Releasing Hormone (MESH:D007987)
294 decreased regulation of luteinizing hormone secretion (GO:0033684) Luteinizing hormone (CHEBI:81568) 531: Decreased, LH Surge
295 delayed abnormal ovulation (MP:0001928) 532: Delayed, Ovulation
296 decreased secretion (GO:0046903) cortical granule (GO:0060473) 533: Decreased, Cortical granule release/distribution upon fertilization
297 abnormal fertilization envelope (GO:0060387) 534: Altered, Formation of cortical envelope
298 abnormal sperm entry (GO:0035037) 535: Abnormal, Sperm penetration (polyspermy)
299 increased abnormal chromosome number (MP:0004023)
300 increased DNA hypermethylation (GO:0044026) 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis