Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 276 to 300 of 1145 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


870	increased	toll-like receptor 4 signaling pathway (GO:0034142)	Toll-like receptor 4 (PR:000001155)	1495: Substance interaction with the lung resident cell membrane components
869	increased	toll-like receptor signaling pathway (GO:0002224)	Toll-like receptor (PR:000001096)	1495: Substance interaction with the lung resident cell membrane components
868	increased	pattern recognition receptor signaling pathway (GO:0002221)		1495: Substance interaction with the lung resident cell membrane components
867	increased	increased lung tumor incidence (MP:0008014)	lung (UBERON:0002048)	1670: Lung cancer
866	increased	Neoplasm of the lung (HP:0100526)	lung (UBERON:0002048)	1670: Lung cancer
865	increased	cell proliferation (GO:0008283)	mesothelial cell (CL:0000077)	870: Increase, Cell Proliferation
864	increased	abnormal DNA repair (MP:0008058)	DNA repair complex (GO:1990391)	1669: Increased, DNA damage and mutation
863	increased	chromosomal instability (MP:0008866)	chromosome (GO:0005694)	2 Events 1669: Increased, DNA damage and mutation 1896: Genomic instability
862	increased	chromosome breakage (GO:0031052)	chromosome (GO:0005694)	2 Events 1669: Increased, DNA damage and mutation 1636: Increase, Chromosomal aberrations
861	increased	mutation (MESH:D009154)		1669: Increased, DNA damage and mutation
860	increased	DNA damage response, detection of DNA damage (GO:0042769)	site of DNA damage (GO:0090734)	2 Events 2006: Secondary genotoxicity 1669: Increased, DNA damage and mutation
859	increased	neutrophil activation (GO:0042119)	neutrophil (CL:0000775)	None
858	increased	macrophage activation (GO:0042116)	macrophage (CL:0000235)	1497: Increased, recruitment of inflammatory cells
857	increased	inflammatory response (GO:0006954)	inflammatory cell (CL:0009002)	1497: Increased, recruitment of inflammatory cells
856	increased		Interleukin (FMA:86578)	1496: Increased, secretion of proinflammatory mediators
855	increased	complement activation (GO:0006956)		1496: Increased, secretion of proinflammatory mediators
854	increased	chemokine secretion (GO:0090195)	Chemokine (FMA:241981)	1496: Increased, secretion of proinflammatory mediators
853	increased	cytokine production involved in inflammatory response (GO:0002534)	Cytokine (FMA:84050)	1496: Increased, secretion of proinflammatory mediators
852	increased		Cytokine (FMA:84050)	None
851	disrupted	action potential (GO:0001508)		1983: Disruption, action potential generation
850	increased	protease binding (GO:0002020)	transmembrane protease serine 2 (human) (PR:O15393)	None
849	increased	neuropilin binding (GO:0038191)	neuropilin-1 (PR:000001900)	None
848	increased		transmembrane protease serine 2 (human) (PR:O15393)	None
847	increased	increased luteinizing hormone level (MP:0005133)	StAR-related lipid transfer protein 6 (PR:000015721)	1972: Increased, Steroidogenic acute regulatory protein (StAR)
846	increased	increased luteinizing hormone level (MP:0005133)	StAR-related lipid transfer protein 5 (PR:000015720)	1972: Increased, Steroidogenic acute regulatory protein (StAR)