Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 501 to 525 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
641 increased endothelial cell proliferation (GO:0001935) 1189: Increased, Proliferation (Endothelial cells)
640 increased estrogen receptor binding (GO:0030331) serotransferrin (PR:000016261) 1188: Increased, ER binding to T.F. to DNA (non-classical pathway)
639 increased estrogen receptor binding (GO:0030331) deoxyribonucleic acid (CHEBI:16991) 1187: Increased, ER binding to DNA (classical pathway)
638 increased signaling (GO:0023052) estrogen receptor (PR:000007204) None
637 decreased transport (GO:0006810) gamma-aminobutyric acid (CHEBI:16865) 1179: Decreased, GABA release
636 decreased transport (GO:0006810) sodium(1+) (CHEBI:29101) 1176: Decreased, sodium conductance 2
635 decreased signaling (GO:0023052) sodium channel protein type 1 subunit alpha (PR:000002095) 584: Inhibition, sodium channel
634 increased oxidation-reduction process (GO:0055114) deoxyribonucleic acid (CHEBI:16991) 1238: Activation of oxidative stress pathway
633 increased oxidation-reduction process (GO:0055114) protein (PR:000000001) 1238: Activation of oxidative stress pathway
632 increased oxidation-reduction process (GO:0055114) plasma membrane (GO:0005886) 1238: Activation of oxidative stress pathway
631 increased reflex (GO:0060004) sneezing (MESH:D012912) 1434: Irritation of nasal mucosa inducing sneeze reflex
630 increased immune response (GO:0006955) 1237: Sensitization, Immune system
629 increased antigen processing and presentation (GO:0019882) hapten (CHEBI:59174) 1236: Generation of novel epitopes , Antigen presentation
628 increased regulation of chemokine (C-X-C motif) ligand 1 production (GO:2000338) growth-regulated alpha protein (PR:000006063) 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation
627 increased cytokine production (GO:0001816) interleukin-8 (PR:000001395) 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation
626 increased cytokine production (GO:0001816) beta-nerve growth factor (PR:000011194) 1234: Production of nerve growth factor , Epithelial irritation
625 increased inflammatory response (GO:0006954) respiratory system (UBERON:0001004) 1226: Increased Respiratory irritability and Chronic Cough,
624 increased abnormal acute inflammation (MP:0002498) 1225: Immune system inflammation
623 increased cytokine production (GO:0001816) tumor necrosis factor alpha (PR:000000134) 1224: Non-neuronal production of TNF, Epithelial irritation
622 increased dermatitis (MP:0001194)
621 increased Dyspnea (MESH:D004417) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
620 increased Respiratory Hypersensitivity (MESH:D012130) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
619 increased cough (MESH:D003371)
618 increased reflex (GO:0060004) trigeminal nerve (UBERON:0001645) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
617 increased neuropeptide hormone activity (GO:0005184) Substance P (CHEBI:80308) 1222: SP (Substance P) release, Local increase of SP