Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 576 to 600 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
566 increased hypertrophy (MESH:D006984) prolactin secreting cell (CL:0000439) 1081: Increased, lactotroph hyperplasia and hypertrophy
565 increased hyperplasia (MESH:D006965) prolactin secreting cell (CL:0000439) 1081: Increased, lactotroph hyperplasia and hypertrophy
564 increased abnormal tumor latency (MP:0010307) 1080: Increased, latency period
563 increased mammary gland hyperplasia (MP:0000630) 1078: Hyperplasia, Mammary gland
562 increased prolactin (PR:000013246) 1077: Increased, prolactin exposure
561 increased estrogen (CHEBI:50114) 1076: Increased, circulating estrogen levels
560 delayed estrus (GO:0060209) None
559 disrupted abnormal ovulation (MP:0001928) 1074: interruption, Ovulation
558 increased adenosquamous carcinoma (MESH:D018196) 1070: Increased, adenosquamous carcinomas of endometrium
557 increased hyperplasia (MESH:D006965) glandular epithelial cell (CL:0000150)
556 morphological change Metaplasia (MESH:D008679) None
555 increased cell proliferation (GO:0008283) basal cell (CL:0000646) 1067: Proliferation/Clonal Expansion, aberrant basal-type cells
554 increased gene expression (GO:0010467) homeobox protein SIX1 (PR:000014896) 2329: Sine oculis homeobox 1 gene expression, increased
553 increased intracellular estrogen receptor signaling pathway (GO:0030520) estrogen receptor alpha complex (PR:000027727) 1065: Activation, estrogen receptor alpha
552 increased cell proliferation (GO:0008283) acinar cell (CL:0000622) 1062: Increased, Cellular proliferation / hyperplasia of acinar cells
551 increased cholecystokinin (PR:000005110) 1061: prolonged, elevation of serun CCK
550 abnormal lipid metabolic process (GO:0006629) 1060: Alteration, lipid metabolism
549 decreased bile (UBERON:0001970) 1058: Decreased, bile flow
548 increased Granular Cell Tumor (MESH:D016586) 1054: Promotion, ovarian granular cell tumors
547 increased hyperplasia (MESH:D006965) epithelium of female gonad (UBERON:0004911) 1052: Hyperplasia, ovarian epithelium
546 increased hyperplasia (MESH:D006965) stromal cell of ovary (CL:0002132) 1051: Hyperplasia, ovarian stromal cells
545 decreased follicle-stimulating hormone secretion (GO:0046884) Follicle stimulating hormone (CHEBI:81569) 1049: Increased, secrection of FSH from anterior pituitary
544 decreased estradiol (CHEBI:23965) 1045: Decreased, Ovarian E2
543 increased leiomyoma (MESH:D007889) 1044: Promotion, mesovarian leiomyomas
542 increased hypertrophy (MESH:D006984) smooth muscle tissue (UBERON:0001135) 1043: Hypertrophy/hyperplasia, smooth muscle