Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 751 to 775 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
391 increased neoplasm (MP:0002006) 745: Increase, Leydig cell tumors
390 increased Leydig cell hyperplasia (MP:0001152) Leydig cell (CL:0000178) 744: Increase, Hyperplasia (Leydig cells)
389 decreased receptor binding (GO:0005102) testosterone (CHEBI:17347) 743: Decreased, Testosterone binding to androgen receptor (hypothalamus)
388 increased Thyroid stimulating hormone (CHEBI:81567)
387 increased hyperplasia (MESH:D006965) thyroid follicular cell (CL:0002258)
386 increased hypertrophy (MESH:D006984) thyroid follicular cell (CL:0002258)
385 increased cell proliferation (GO:0008283) thyroid follicular cell (CL:0002258)
384 increased cell death (GO:0008219) Clara cell (CL:0000158) 770: Increase, Cytotoxicity (club cells)
383 increased hyperplasia (MESH:D006965) bronchial epithelial cell (CL:0002328) 735: Increase, Hyperplasia (terminal bronchiolar cells)
382 increased epithelial cell proliferation (GO:0050673) bronchial epithelial cell (CL:0002328) 734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
381 increased cell death (GO:0008219) bronchial epithelial cell (CL:0002328) 733: Increase, Necrosis (terminal bronchiolar cells)
380 decreased pyruvate dehydrogenase activity (GO:0004738) Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (rat) (PR:Q63065) 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
379 increased pyruvate dehydrogenase activity (GO:0004738) pyruvate dehydrogenase [ubiquinone] (PR:000023575) 726: Increased, Induction of pyruvate dehydrogenase (PDH)
378 increased cellular respiration (GO:0045333) 769: Increase, Oxidative metabolism
377 abnormal regulation of gene expression (GO:0010468) 1214: Altered gene expression specific to CAR activation, Hepatocytes
376 increased preneoplasia (MP:0002009) abnormal cell mass (MP:0003902) 774: Increase, Preneoplastic foci (hepatocytes)
375 increased cell proliferation (GO:0008283) mitogenic signaling cell (CL:0000422) 716: Increase, cell proliferation (hepatocytes)
374 decreased spindle organization (GO:0007051) spindle (GO:0005819) 721: Disorganization, Meiotic Spindle
373 increased microtubule depolymerization (GO:0007019) microtubule (GO:0005874) 720: Disruption, Microtubule dynamics
372 increased tubulin binding (GO:0015631) tubulin (PR:000028799) 718: Binding, Tubulin
371 abnormal chromosome movement towards spindle pole (GO:0051305) chromosome (GO:0005694) 752: Altered, Meiotic chromosome dynamics
370 increased binding (GO:0005488) major urinary protein (rat) (PR:P02761) 714: Increased, Binding of chemicals to 2u (serum)
369 increased major urinary protein (rat) (PR:P02761) 708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
368 increased hyperplasia (MESH:D006965) kidney tubule cell (CL:1000507) 767: Increase, Hyperplasia (renal tubular cells)
367 increased Carcinoma (MESH:D002277)