Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 951 to 975 of 1145 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


195	increased	chemokine activity (GO:0008009)	Chemokine (FMA:241981)	151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
194	increased	covalent binding (MI:0195)	xenobiotic (CHEBI:35703)	75: N/A, Covalent binding to protein, possibly lysine residue
193	increased	transforming growth factor beta1 production (GO:0032905)	TGF-beta 1 (PR:000000182)	276: Up Regulation, TGFbeta1 expression
192	occurrence	liver fibrosis (MP:0003333)	liver (UBERON:0002107)	2 Events 344: Increase, Liver fibrosis 840: Formation, Liver fibrosis
191	increased	macrophage activation (GO:0042116)	Kupffer cell (CL:0000091)	134: Increase, Kupffer cell activation
190	increased	protein alkylation (GO:0008213)		244: Alkylation, Protein
189	increased	hepatic stellate cell activation (GO:0035733)	hepatic stellate cell (CL:0000632)	265: Increase, Hepatic stellate cell activation
188	increased	collagen biosynthetic process (GO:0032964)	collagen (CHEBI:3815)	68: Increase, Collagen accumulation
187	increased		fatty liver (MESH:D005234)	None
186	decreased	3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857)	3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)	2 Events 8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
185	decreased	gene expression (GO:0010467)	3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)	140: Decreased, HSD17B10 expression
184	increased		fatty acid (CHEBI:35366)	327: Accumulation, Fatty acid
183	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor gamma (PR:000013058)	2 Events 233: Decreased, PPAR-gamma activation 1028: Activation of specific nuclear receptors, PPAR-gamma activation
182	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor delta (PR:000013057)	232: Decreased, PPAR-beta activation
181	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor alpha (PR:000013056)	3 Events 231: Decreased, PPAR-alpha activation 468: Inhibition, PPAR alpha 1057: Increased, PPAR-alpha activation
180	abnormal		plasma membrane (GO:0005886)	169: Disruption, Membrane integrity
179	increased		membrane (GO:0016020)	46: Accumulation, Biological membranes
178	occurrence		fatty liver (MESH:D005234)	345: N/A, Liver Steatosis
177	functional change	mitochondrion disassembly (GO:0061726)	mitochondrion (GO:0005739)	None
176	increased		triglyceride (CHEBI:17855)	291: Accumulation, Triglyceride
175	increased	fatty acid biosynthetic process (GO:0006633)	fatty acid (CHEBI:35366)	2 Events 89: Synthesis, De Novo Fatty Acid (FA) 458: Increased, De Novo FA synthesis
174	increased	gene expression (GO:0010467)	acyl-CoA desaturase (PR:000014497)	2 Events 258: Activation, SCD-1 462: Up Regulation, SCD-1
173	increased	fatty acid synthase activity (GO:0004312)	fatty acid synthase (PR:000007348)	116: Activation, FAS
172	increased	SREBP signaling pathway (GO:0032933)	sterol regulatory element-binding protein 1 (PR:000015611)	3 Events 264: Activation, SREBP-1c 878: Inhibition, SREBP1c 457: Activation, SREBF1
171	increased	signaling (GO:0023052)	carbohydrate-responsive element-binding protein (PR:000010460)	66: Activation, ChREBP