Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 951 to 975 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
191 increased macrophage activation (GO:0042116) Kupffer cell (CL:0000091) 134: Increase, Kupffer cell activation
190 increased protein alkylation (GO:0008213) 244: Alkylation, Protein
189 increased hepatic stellate cell activation (GO:0035733) hepatic stellate cell (CL:0000632) 265: Increase, Hepatic stellate cell activation
188 increased collagen biosynthetic process (GO:0032964) collagen (CHEBI:3815) 68: Increase, Collagen accumulation
187 increased fatty liver (MESH:D005234) None
186 decreased 3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857) 3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)
185 decreased gene expression (GO:0010467) 3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774) 140: Decreased, HSD17B10 expression
184 increased fatty acid (CHEBI:35366) 327: Accumulation, Fatty acid
183 decreased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor gamma (PR:000013058)
182 decreased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor delta (PR:000013057) 232: Decreased, PPAR-beta activation
181 decreased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor alpha (PR:000013056)
180 abnormal plasma membrane (GO:0005886) 169: Disruption, Membrane integrity
179 increased membrane (GO:0016020) 46: Accumulation, Biological membranes
178 occurrence fatty liver (MESH:D005234) 345: N/A, Liver Steatosis
177 functional change mitochondrion disassembly (GO:0061726) mitochondrion (GO:0005739) None
176 increased triglyceride (CHEBI:17855) 291: Accumulation, Triglyceride
175 increased fatty acid biosynthetic process (GO:0006633) fatty acid (CHEBI:35366)
174 increased gene expression (GO:0010467) acyl-CoA desaturase (PR:000014497)
173 increased fatty acid synthase activity (GO:0004312) fatty acid synthase (PR:000007348) 116: Activation, FAS
172 increased SREBP signaling pathway (GO:0032933) sterol regulatory element-binding protein 1 (PR:000015611)
171 increased signaling (GO:0023052) carbohydrate-responsive element-binding protein (PR:000010460) 66: Activation, ChREBP
170 increased positive regulation of fatty acid transport (GO:2000193) fatty acid (CHEBI:35366) 115: Increase, Fatty acid influx
169 increased gene expression (GO:0010467) platelet glycoprotein 4 (PR:000001905) 54: Up Regulation, CD36
168 increased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor gamma (PR:000013058) 228: peroxisome proliferator activated receptor promoter demethylation
167 increased signaling (GO:0023052) oxysterols receptor LXR-alpha (PR:000011395)