Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1101 to 1125 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1101 decreased dendritic spine morphogenesis (GO:0060997) actin cytoskeleton (GO:0015629) 2078: Loss of drebrin
1102 increased regulation of actin-dependent ATPase activity (GO:1904621) actin cytoskeleton (GO:0015629) 2078: Loss of drebrin
1103 increased homeobox protein SIX1 (PR:000014896) None
1104 increased increased synaptic depression (MP:0002916) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
1105 increased receptor agonist activity (GO:0048018) estrogen receptor (PR:000007204) 111: Agonism, Estrogen receptor
1106 abnormal cell differentiation (GO:0030154) cell (GO:0005623) 1560: Cell differentiation, altered
1107 increased Metaplasia (MESH:D008679) Squamous cell (FMA:66769)
1108 increased Endometrial carcinoma (HP:0012114) adenosquamous carcinoma (MESH:D018196) 1070: Increased, adenosquamous carcinomas of endometrium
1109 increased Metaplasia (MESH:D008679) endometrium epithelium (UBERON:0004811) 1068: Endometrial squamous metaplasia, Increase
1110 decreased cellular response to oxidative stress (GO:0034599) 1869: Diminished protective oxidative stress response
1111 increased translation (GO:0006412) homeobox protein SIX1 (PR:000014896) 2330: Sine oculis homeobox 1 protein expression, increased
1112 increased cell proliferation (GO:0008283) homeobox protein SIX1 (PR:000014896) 1066: Promotion, Sine oculis homeobox 1 positive progenitor cells in endometrium
1113 decreased G-protein coupled receptor signaling pathway (GO:0007186) alpha-1A adrenergic receptor (PR:000001183) 2370: Antagonism binding, α1-Adrenoreceptor
1114 increased peptide biosynthetic process (GO:0043043) 2371: Increased cortisol
1115 decreased Decreased activity of mitochondrial complex III (HP:0011924) mitochondrial respiratory chain complex III (GO:0005750) 1542: Inhibition, Mitochondrial complex III
1116 increased estrogen receptor activity (GO:0030284) estrogen receptor alpha complex (PR:000027727) 1065: Activation, estrogen receptor alpha
1117 decreased Decreased circulating gonadotropin level (HP:0030339) circulatory system (UBERON:0001009) 1986: Decreased, Gonadotropins
1118 increased prolonged estrous cycle (MP:0009006) 1075: prolonged, estrus cycle
1119 increased prolonged estrus (MP:0009017) 1075: prolonged, estrus cycle
1120 decreased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 968: Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons
1121 increased hormone secretion (GO:0046879) gonadotropin releasing neuron (CL:0011111) 2137: Increase, Gonadotropins concentration in plasma
1122 increased hormone secretion (GO:0046879) Gonadotropin Releasing Hormone (MESH:D007987) 1047: Increased, secretion of GnRH from hypothalamus
1123 decreased regulation of vascular permeability (GO:0043114) None
1124 increased regulation of vascular permeability (GO:0043114) 2384: Decrease, Vascular integrity
1125 decreased mRNA transcription (GO:0009299) undifferentiated genital tubercle (UBERON:0005876) None